Anti-Mouse IL-4 Antibody (11B11) 

Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combined with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for researches on cancer and inflammation conditions such as colorectal cancer and prostatitis^[1][2][3].

Rat IgG1 kappa

Rat IgG1 kappa, Isotype Control

Mouse

Anti-Mouse IL-4 Antibody (11B11) (10 μg/mL) helps to inhibit Th2 cell differentiation in the presence of TGF-β1 and IL-2 in CD4^{+ T cells from spleen of experimental autoimmune prostatitis (EAP) mice[2] .}

Anti-Mouse IL-4 Antibody (11B11) (1 mg/kg, i.p., once daily, for 10 days) significantly increases the incidence of arthritis in female DBA/1J mice with type II collagen induced arthritis^[1].
Anti-Mouse IL-4 Antibody (11B11) (500 μg/mouse, i.p., single dose, 1 hour before APTKA mCherry organoid injection) significantly reduces collagen deposition and Col1a1 expression by blocking the IL-4/IL-13 signaling pathway combined with anti-IL-13 mAb in C57BL/6 mice bearing APTKA mCherry organoid^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

16189  [NCBI]

P07750

ELISA, FACS, Functional assay, Research in vivo

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

150 kDa

Liquid

Colorless to light yellow

[Anti-Mouse IL-4 Antibody (11B11)]

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Yoshino S. Effect of a monoclonal antibody against interleukin-4 on collagen-induced arthritis in mice. Br J Pharmacol. 1998 Jan;123(2):237-42.  [Content Brief]

  [2]. Guan Y, et al. IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis. J Inflamm Res. 2025 Apr 30;18:5759-5775.  [Content Brief]

  [3]. Nater M, et al. Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver. iScience. 2025 Apr 6;28(5):112364.  [Content Brief]