Il4 - interleukin 4 Gene

Also Known as Il-4; BSF-1

Species: Mus musculus

Gene Type: protein coding

Gene ID: 16189

About Il4

Chromosome 11: 53,493,809-53,509,496 reverse strand.GRCm39:CM001004.3

This gene has 4 transcripts (splice variants), 92 orthologues and is associated with 61 phenotypes. Low expression observed in reference dataset.

Summary

Enables cytokine activity. Involved in several processes, including innate immune response in mucosa; negative regulation of white fat cell proliferation; and regulation of gene expression. Acts upstream of or within several processes, including T-helper cell differentiation; positive regulation of macromolecule metabolic process; and regulation of leukocyte activation. Located in external side of plasma membrane and extracellular space. Is expressed in several structures, including brain; colon; hemolymphoid system; liver; and placenta. Used to study Sjogren's syndrome; atopic dermatitis; and type 1 diabetes mellitus. Human ortholog(s) of this gene implicated in several diseases, including asthma (multiple); autoimmune disease (multiple); hepatitis B; hepatitis C; and pancreatic Cancer (multiple). Orthologous to human IL4 (interleukin 4). [provided by Alliance of Genome Resources, Apr 2022]

Il4 Products (1)

mRNA	Protein	Name
NM_021283.2	NP_067258.1	interleukin-4 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables cytokine activity	IDA IDA: Inferred from direct assay	1588041	MGI

Biological Process GO Annotation	Evidence	Verweise	Source
acts upstream of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within B cell costimulation	IDA IDA: Inferred from direct assay	18762567	MGI
acts upstream of B cell proliferation	IDA IDA: Inferred from direct assay	10979977	MGI
acts upstream of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of or within T-helper 1 cell lineage commitment	IGI IGI: Inferred from genetic interaction	20706986	MGI
acts upstream of or within T-helper 2 cell differentiation	IDA IDA: Inferred from direct assay	20706986	MGI
acts upstream of activated T cell proliferation	IDA IDA: Inferred from direct assay	9841920	MGI
involved in cholesterol metabolic process	IMP IMP: Inferred from mutant phenotype	11971948	MGI
acts upstream of or within defense response to protozoan	IMP IMP: Inferred from mutant phenotype	7927664	MGI
acts upstream of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within extrinsic apoptotic signaling pathway in absence of ligand	IDA IDA: Inferred from direct assay	12115603	MGI
involved in innate immune response in mucosa	IDA IDA: Inferred from direct assay	9973465	MGI
acts upstream of isotype switching to IgE isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of isotype switching to IgG isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of or within negative regulation of T cell activation	IDA IDA: Inferred from direct assay	18997793	MGI
acts upstream of or within negative regulation of T-helper 17 cell differentiation	IDA IDA: Inferred from direct assay	18792410	MGI
acts upstream of or within negative regulation of extrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	10429671	MGI
acts upstream of or within negative regulation of osteoclast differentiation	IDA IDA: Inferred from direct assay	12941478	MGI
involved in negative regulation of tumor necrosis factor production	IDA IDA: Inferred from direct assay	29061364	MGI
involved in negative regulation of white fat cell proliferation	IDA IDA: Inferred from direct assay	24347527	MGI
acts upstream of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8022486	MGI
involved in positive regulation of ATP biosynthetic process	IDA IDA: Inferred from direct assay	29061364	MGI
acts upstream of or within positive regulation of B cell activation	IDA IDA: Inferred from direct assay	8566034	MGI
acts upstream of or within positive regulation of B cell proliferation	IDA IDA: Inferred from direct assay	10979977	MGI
involved in positive regulation of DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	7749983	MGI
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	7749983	MGI
acts upstream of or within positive regulation of MHC class II biosynthetic process	IDA IDA: Inferred from direct assay	10549626	MGI
acts upstream of or within positive regulation of T cell proliferation	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of or within positive regulation of activated T cell proliferation	IDA IDA: Inferred from direct assay	9841920	MGI
involved in positive regulation of amyloid-beta clearance	IDA IDA: Inferred from direct assay	18941241	MGI
involved in positive regulation of cellular respiration	IDA IDA: Inferred from direct assay	29061364	MGI
involved in positive regulation of chemokine production	IDA IDA: Inferred from direct assay	9013979	MGI
involved in positive regulation of cold-induced thermogenesis	IMP IMP: Inferred from mutant phenotype	24906148	MGI
involved in positive regulation of gene expression	IDA IDA: Inferred from direct assay	29061364	MGI
acts upstream of or within positive regulation of immunoglobulin production	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of immunoglobulin production	IMP IMP: Inferred from mutant phenotype	15944273	MGI
acts upstream of or within positive regulation of isotype switching to IgE isotypes	IDA IDA: Inferred from direct assay	14988498	MGI
acts upstream of or within positive regulation of isotype switching to IgG isotypes	IDA IDA: Inferred from direct assay	12882831	MGI
involved in positive regulation of macroautophagy	IDA IDA: Inferred from direct assay	26416964	MGI
acts upstream of or within positive regulation of mast cell degranulation	IGI IGI: Inferred from genetic interaction	15944273	MGI
acts upstream of or within positive regulation of mast cell degranulation	IMP IMP: Inferred from mutant phenotype	15944273	MGI
acts upstream of or within positive regulation of myoblast fusion	IDA IDA: Inferred from direct assay	12757709	MGI
acts upstream of or within positive regulation of myoblast fusion	IMP IMP: Inferred from mutant phenotype	12757709	MGI
acts upstream of or within positive regulation of peptidyl-tyrosine phosphorylation	IDA IDA: Inferred from direct assay	8022486	MGI
acts upstream of or within positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	12115603	MGI
involved in positive regulation of receptor-mediated endocytosis	IDA IDA: Inferred from direct assay	18941241	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1588041	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15187136	MGI
acts upstream of or within positive regulation of transcription by RNA polymerase II	IGI IGI: Inferred from genetic interaction	9110977	MGI
acts upstream of or within positive regulation of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI
acts upstream of or within regulation of immune response	IDA IDA: Inferred from direct assay	12882831	MGI
acts upstream of or within response to nematode	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of or within response to selenium ion	IDA IDA: Inferred from direct assay	26644468	MGI
acts upstream of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	1588041	MGI
acts upstream of tyrosine phosphorylation of STAT protein	IDA IDA: Inferred from direct assay	10485657	MGI

Cellular Component GO Annotation	Evidence	Verweise	Source
located in external side of plasma membrane	IDA IDA: Inferred from direct assay	19666510	MGI
located in extracellular space	IDA IDA: Inferred from direct assay	11057672	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Il4 Protein Structure

IL4_13

0
100
140 a.a.

Protein Preferred Names	Protein Names
interleukin-4	B-cell IgG differentiation factor B-cell growth factor 1 B-cell stimulatory factor 1 IGG1 induction factor lymphocyte stimulatory factor 1

Recombinant Il4 Proteins

Art. -Nr.	Produktname	Accession	Reinheit
HY-P7080	IL-4 Protein, Mouse (CHO)	P07750 (H21-S140)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70644	IL-4 Protein, Mouse	P07750 (H23-S140)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P70653	IL-4 Protein, Mouse (HEK293, His)	P07750 (H21-S140)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P73215	IL-4 Protein, Mouse (Q136D, Y139D, sf9, His)	P07750 (H21-S140, Q136D, Y139D)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P700214AF	Animal-Free IL-4 Protein, Mouse (His)	P07750 (H21-S140)	≥ 95%, as determined by reducing SDS-PAGE.
HY-P701093	IL-4 Protein, Mouse (HEK293)	P07750 (H21-S140)	≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

Approval
Clinical Phase
Pre-clinical Phase

Approval

Bioactive Molecules (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-B0539	Desloratadine		99.98%	Yes
HY-B0640	Epinastine		98.0%	Unkown
HY-B1076	Medrysone		99.79%	Unkown
HY-108013	Armillarisin A		99.79%	Unkown
HY-17002	Suplatast (Tosilate)	Inhibitor	99.67%	Unkown
HY-B0640A	Epinastine hydrochloride		99.86%	Unkown
HY-B0446	Naphazoline hydrochloride		99.38%	Unkown
HY-111326A	Naphazoline nitrate		99.12%	Unkown
HY-111326	Naphazoline		99.74%	Unkown
HY-B0010C	(S,S)-Formoterol	Activator	/	Unkown
HY-B0640AR	Epinastine hydrochloride (Standard)		/	Unkown

Inhibitory Antibodies (2)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P9926	Dupilumab	Inhibitor	≥99.2%	Unkown
HY-P99025	Lebrikizumab	Inhibitor	99.90%	Unkown

Clinical Phase

Bioactive Molecules (5)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-154629	Sesame Oil	Inhibitor	98.2%	Phase 4
HY-13743	Roquinimex	Inhibitor	99.69%	Phase 3
HY-13743R	Roquinimex (Standard)	Inhibitor	/	Phase 3
HY-144683	PF-07038124	Inhibitor	/	Phase 2
HY-113402B	Gamma-glutamylcysteine ammonium		/	Phase 1

Inhibitory Antibodies (11)

Art. -Nr.	Produktname	Wirkung	Reinheit	Phase
HY-P990093	Stapokibart	Inhibitor	99.37%	Phase 4
HY-P990090	Rademikibart	Inhibitor	99.13%	Phase 3
HY-P99724	Manfidokimab		95.00%	Phase 3
HY-P990983	Drotokibart	Inhibitor	97.05%	Phase 3
HY-P991515	TQH-2722	Inhibitor	/	Phase 3
HY-P990910	Comekibart	Inhibitor	97.43%	Phase 2
HY-P991266	SM-17	Inhibitor	96.98%	Phase 2
HY-P99883	Romilkimab	Inhibitor	99.01%	Phase 2
HY-P990708	Bizaxofusp		/	Phase 2
HY-P991633	TQC2938	Inhibitor	/	Phase 2
HY-P991285	MEDI-9314	Inhibitor	/	Phase 1

Pre-clinical Phase

Bioactive Molecules (82)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-126360	Oxazolone		98.0%	Unkown
HY-113402	Gamma-glutamylcysteine		98.53%	Unkown
HY-134771	YM-341619	Inhibitor	98.01%	Unkown
HY-139092	IL-4-inhibitor-1	Inhibitor	98.04%	Unkown
HY-N6013	Aloin (mixture of A&B)		99.36%	Unkown
HY-W013579	(S)-(+)-Carvone		99.26%	Unkown
HY-145551	Atinvicitinib	Inhibitor	98.62%	Unkown
HY-113402A	Gamma-glutamylcysteine TFA		96.68%	Unkown
HY-174262	IL4I1-IN-1	Inhibitor	99.95%	Unkown
HY-NP159	House Dust Mite Extract, from D.farinae	Activator	/	Unkown
HY-171034	PQA-18	Inhibitor	99.62%	Unkown
HY-N4087	Platycodin D2	Inducer	99.84%	Unkown
HY-N15135	Arabinoxylan (Medium viscosity)		95.0%	Unkown
HY-N1921	Edpetiline	Inhibitor	99.81%	Unkown
HY-N1938	D(+)-Raffinose pentahydrate		≥98.0%	Unkown
HY-141582	Ceramide 3	Inhibitor	98.0%	Unkown
HY-144683A	PF-07038124 hydrochloride	Inhibitor	99.26%	Unkown
HY-N0600	Ginsenoside F3		99.84%	Unkown
HY-207120	TSLP-IN-1	Inhibitor	99.67%	Unkown
HY-N0646	Silydianin		99.71%	Unkown
HY-113402R	Gamma-glutamylcysteine (Standard)		98.14%	Unkown
HY-162248	JAK1/2-IN-1	Inhibitor	98.36%	Unkown
HY-206870	BP79	Inhibitor	/	Unkown
HY-N2426	Clerodendrin	Inhibitor	99.66%	Unkown
HY-125019	iJak-381	Inhibitor	99.86%	Unkown
HY-169859	EP4 receptor antagonist 7	Antagonist	99.9%	Unkown
HY-181006	TSLP modulator-1	Inhibitor	99.61%	Unkown
HY-N2492	(E)-Methyl 4-coumarate		99.87%	Unkown
HY-15131	PNRI-299	Inhibitor	/	Unkown
HY-N10116A	Calamenene		/	Unkown
HY-P11143	IL4RPep-1		/	Unkown
HY-P11143A	IL4RPep-1 acetate		98.61%	Unkown
HY-RS06769	IL4R Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-113402AR	Gamma-glutamylcysteine TFA (Standard)		/	Unkown
HY-141582S	Ceramide 3-d3	Inhibitor	98.0%	Unkown
HY-184554	ZY-MY-111	Inhibitor	/	Unkown
HY-106979	Olcorolimus	Inhibitor	/	Unkown
HY-116585	C6 D-Threo Ceramide (d18:1/6:0)	Activator	/	Unkown
HY-116609	C6 L-threo Ceramide	Inhibitor	/	Unkown
HY-144684	PDE4-IN-8	Inhibitor	/	Unkown
HY-155951	JAK3-IN-14	Inhibitor	99.32%	Unkown
HY-162404	(14S,15R)-14-Deoxyoxacyclododecindione	Inhibitor	/	Unkown
HY-162405	STAT6-IN-12	Inhibitor	/	Unkown
HY-162726	GCS-11	Activator	/	Unkown
HY-162727	GCS-12		/	Unkown
HY-163670	TLR7 agonist 21	Inhibitor	/	Unkown
HY-163704	KRN7000 analog 1		/	Unkown
HY-165484	AVP-13358	Inhibitor	/	Unkown
HY-172806	PARP14 inhibitor 1	Inhibitor	/	Unkown
HY-174395	CD-10		/	Unkown
HY-175650	STAT6-IN-9	Inhibitor	98.11%	Unkown
HY-175876	ADAM17-IN-1	Inhibitor	/	Unkown
HY-176456	PARP14 inhibitor 2	Inhibitor	/	Unkown
HY-181739	GCB-27a	Activator	/	Unkown
HY-181740	GCB-27b	Activator	/	Unkown
HY-182335	PF-07245303	Inhibitor	/	Unkown
HY-182795	Colchicine derivative-1		/	Unkown
HY-183548	XW-17	Ligand	/	Unkown
HY-184897	YS-01	Inhibitor	/	Unkown
HY-186103	Glycolipid C34	Inhibitor	/	Unkown
HY-187161	IL-4-IN-3		/	Unkown
HY-N15708	Dichotomine C	Inhibitor	/	Unkown
HY-P11004	A3-APO	Inhibitor	/	Unkown
HY-RS06765	IL4 Human Pre-designed siRNA Set A		/	Unkown
HY-RS06766	Il4 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS06767	Il4 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS06768	IL4I1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-124273	C2 L-threo Ceramide (d18:1/2:0)		/	Unkown
HY-124613	Pyrazinib	Inhibitor	/	Unkown
HY-169864	KRO-105714	Antagonist	/	Unkown
HY-171004	KRN7000 analog 8		/	Unkown
HY-174603	Human IL4R mRNA		/	Unkown
HY-174604	Human IL4 mRNA		96.4%	Unkown
HY-174638	Human IL13RA1 mRNA		/	Unkown
HY-187160	IL-4-IN-2	Inhibitor	/	Unkown
HY-N3312S	Matairesinol-d6		/	Unkown
HY-N3989	Haplopine		99.49%	Unkown
HY-N6013R	Aloin (mixture of A&B) (Standard)		/	Unkown
HY-RS17465	Il4i1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23551	Il4r Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23923	Il4i1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W553071	Cytoxazone	Inhibitor	/	Unkown

Inhibitory Antibodies (20)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-P990121	Anti-Mouse IL-4 Antibody (11B11)	Inhibitor	97.67%	Unkown
HY-P990837	Anti-IL-4 Antibody (MP4-25D2)	Inhibitor	≥95.0%	Unkown
HY-P991162	Tilrekimig	Inhibitor	97.00%	Unkown
HY-P992033	Anti-Mouse IL-4Rα Antibody (REGN1103)	Antagonist	99.90%	Unkown
HY-P991031	Telikibart	Inhibitor	97.505%	Unkown
HY-P990122	Anti-Rat IL-4 Antibody (OX-81)	Inhibitor	95.00%	Unkown
HY-P990800	Anti-Mouse IL-4 Antibody (BVD6-24G2)		96.486%	Unkown
HY-P991150	Ompekimig	Inhibitor	/	Unkown
HY-P991152	Oturkibart	Inhibitor	99.49%	Unkown
HY-P991675	Camtarkibart	Inhibitor	99.41%	Unkown
HY-P991688	Gimvekibart	Inhibitor	95.50%	Unkown
HY-P992034	APG808	Inhibitor	/	Unkown
HY-P990292	Anti-Mouse CD132 (common γ chain) Antibody (3E12)	Inhibitor	/	Unkown
HY-P991283	AMG-317	Inhibitor	/	Unkown
HY-P991777	Anti-Mouse CD86/B7-2 Antibody (2D10)	Inhibitor	/	Unkown
HY-P992000	F8-IL-4		/	Unkown
HY-P992064	Anti-Mouse IL-4 Antibody (11B.11)	Inhibitor	/	Unkown
HY-P992150	Altrakincept	Inhibitor	/	Unkown
HY-P992447	QX008N	Inhibitor	/	Unkown
HY-P992480	VAK-694	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Il4	NCBI	NCBI:3565