AVP-13358
AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses.
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- No. CAS: 459805-03-9
- Fòrmula: C30H29N5O2
- Peso molecular:491.58
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Almacenamiento:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Actividad biológica
Descripciòn
IC50 & Target
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IL-5 |
IL-13 |
IL-4 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| B-cell | IC50 |
8 nM
Compound: 1i, AVP-13358
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Inhibition of IgE production in B lymphocytes from BALB/c mouse
Inhibition of IgE production in B lymphocytes from BALB/c mouse
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[PMID: 15588078] |
| Lymphocyte | IC50 |
20 nM
Compound: 1i, AVP-13358
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Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized CD14-positive human peripheral blood lymphocytes
Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized CD14-positive human peripheral blood lymphocytes
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[PMID: 15588078] |
| Splenocyte | IC50 |
100 nM
Compound: 1i, AVP-13358
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Suppression of IL4 receptor alpha expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes
Suppression of IL4 receptor alpha expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes
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[PMID: 15588078] |
| Splenocyte | IC50 |
40 nM
Compound: 1i, AVP-13358
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Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes
Suppression of CD23 expression in IL4 and anti-CD3 antibody sensitized mouse splenocytes
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[PMID: 15588078] |
| T-cell | IC50 |
30 nM
Compound: 1i, AVP-13358
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Inhibition of IL13 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
Inhibition of IL13 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
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[PMID: 15588078] |
| T-cell | IC50 |
30 nM
Compound: 1i, AVP-13358
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Inhibition of IL4 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
Inhibition of IL4 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
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[PMID: 15588078] |
| T-cell | IC50 |
30 nM
Compound: 1i, AVP-13358
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Inhibition of IL5 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
Inhibition of IL5 production in conA and anti-CD3 antibody sensitized BALB/c mouse spleen T lymphocytes
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[PMID: 15588078] |
| Vero | IC50 |
>2000 nM
Compound: 1d
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Antiviral activity against SV40-infected Vero cells
Antiviral activity against SV40-infected Vero cells
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[PMID: 17973358] |
| Vero | IC50 |
>2000 nM
Compound: 1d
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Antiviral activity against VSV-infected Vero cells
Antiviral activity against VSV-infected Vero cells
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[PMID: 17973358] |
Chemical Information
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No. CAS 459805-03-9
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Peso molecular 491.58
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Fòrmula C30H29N5O2
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SMILES
O=C(C1=CC=C2N=C(C3=CC=C(NC(C45CC6CC(C5)CC(C4)C6)=O)C=C3)NC2=C1)NC7=NC=CC=C7
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Envío
Room temperature in continental US; may vary elsewhere.
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Almacenamiento
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureza y Documentación
Referencias
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
AVP-13358 Related Classifications
HY-165484 Related Classifications
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