459805-03-9
Chemical Structure
AVP-13358
- CAS No.: 459805-03-9
- Formula:C30H29N5O2
- Molecular Weight:491.58
InChIKey: LUPHOOKVGNVAFT-UHFFFAOYSA-N
SMILES: O=C(C1=CC=C2N=C(C3=CC=C(NC(C45CC6CC(C5)CC(C4)C6)=O)C=C3)NC2=C1)NC7=NC=CC=C7
Biological Activity: AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses[1].
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AVP-13358 | AVP-13358 is an orally active IgE inhibitor that effectively suppresses immunoglobulin E (IgE)-mediated immune responses, with IC50 values of 8 and 3 nM for IgE inhibition in vivo and in vitro in BALB/c mice, respectively. AVP-13358 acts directly on T cells, inhibiting the production and release of IL-4, IL-5, and IL-13. It also targets other markers critical for the development of allergic responses, including the B cell IgE receptor (CD23) in human monocytes and the CD23 and IL-4 receptors in mouse B cells. AVP-13358 can be used in research related to anti-allergic responses. | |||||||||||||||||||||
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Keywords
