PARP14 inhibitor 2
PARP14 inhibitor 2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of <30 nM. PARP14 inhibitor 2 inhibits the mono-ADP-ribosyltransferase activity of PARP14 and regulates IFN-γ and IL-4 signaling, reversing protumor macrophage polarization and inhibiting anti-tumor inflammatory responses. PARP14 inhibitor 2 is promising for research of PARP14-related diseases such as tumors, atopic dermatitis and autoimmune diseases.
For research use only. We do not sell to patients.
- CAS No.: 3064731-00-3
- Formula: C25H32FN3O4S
- Molecular Weight:489.60
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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PARP14 <30 nM (IC50) |
Chemical Information
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CAS No. 3064731-00-3
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Molecular Weight 489.60
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Formula C25H32FN3O4S
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SMILES
O=C1N=C(CSC2CCOCC2)NC3=CC(OCC45CCC(CC4)(CC5)NC(C)=O)=CC(F)=C13
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
PARP14 inhibitor 2 Related Classifications
HY-176456 Related Classifications
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