3064731-00-3
Chemical Structure
PARP14 inhibitor 2
- CAS No.: 3064731-00-3
- Formula:C25H32FN3O4S
- Molecular Weight:489.60
SMILES: O=C1N=C(CSC2CCOCC2)NC3=CC(OCC45CCC(CC4)(CC5)NC(C)=O)=CC(F)=C13
Biological Activity: PARP14 inhibitor 2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of <30 nM. PARP14 inhibitor 2 inhibits the mono-ADP-ribosyltransferase activity of PARP14 and regulates IFN-γ and IL-4 signaling, reversing protumor macrophage polarization and inhibiting anti-tumor inflammatory responses. PARP14 inhibitor 2 is promising for research of PARP14-related diseases such as tumors, atopic dermatitis and autoimmune diseases[1].
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PARP14 inhibitor 2 | PARP14 inhibitor 2 (Compound 3) is an orally active and highly selective PARP14 inhibitor with an IC50 value of <30 nM. PARP14 inhibitor 2 inhibits the mono-ADP-ribosyltransferase activity of PARP14 and regulates IFN-γ and IL-4 signaling, reversing protumor macrophage polarization and inhibiting anti-tumor inflammatory responses. PARP14 inhibitor 2 is promising for research of PARP14-related diseases such as tumors, atopic dermatitis and autoimmune diseases. | |||||||||||||||||||||
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Keywords
