2. Immunology/Inflammation
  3. Interleukin Related
  4. TSLP-IN-1

TSLP-IN-1 is a potent thymic stromal lymphopoietin (TSLP) inhibitor. TSLP-IN-1 disrupts TSLP-TSLPR protein-protein interaction, and downregulates IL-4 and IL-13. TSLP-IN-1 can be used for the research of inflammation diseases, such as skin disease, asthma, and allergies.

For research use only. We do not sell to patients.

TSLP-IN-1

TSLP-IN-1 Chemical Structure

CAS No. : 512837-95-5

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Based on 1 publication(s) in Google Scholar

TSLP-IN-1 Related Antibodies

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View All Interleukin Related Isoform Specific Products:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

TSLP-IN-1 is a potent thymic stromal lymphopoietin (TSLP) inhibitor. TSLP-IN-1 disrupts TSLP-TSLPR protein-protein interaction, and downregulates IL-4 and IL-13. TSLP-IN-1 can be used for the research of inflammation diseases, such as skin disease, asthma, and allergies[1].

IC50 & Target[1]

IL-4

 

IL-13

 

In Vitro

TSLP-IN-1 (compound C13) (0.25-20 μM; 24 h) selectively inhibits proliferation of Hut78 cells, while showing no cytotoxicity in human keratinocytes and fibroblasts[1].
TSLP-IN-1 (0.25-20 μM; 36 h) inhibits IL-4 and IL-13 release in TSLP-activated HuT78 cells and human primary CD4+T cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

TSLP-IN-1 Related Antibodies

Cell Viability Assay[1]

Cell Line: Primary human keratinocytes, dermal fibroblasts, and HuT78 cells
Concentration: 0.25; 0.5; 1; 2.5; 5; 10; 20 μM
Incubation Time: 24 h
Result: Exhibited strong inhibitory effects at 20 μΜ in Hut78 cells.
Induced no major cytotoxicity in primary human keratinocytes and fibroblasts.

ELISA Assay[1]

Cell Line: TSLP-activated HuT78 cells, human
primary CD4+T cells
Concentration: 0.25; 0.5; 1; 2.5; 5; 10; 20 μM
Incubation Time: 36 h
Result: Significantly reduced TSLP-triggered IL-4 and IL-13 release in a concentration-dependent manner.
Showed strong inhibitory effects at 20 μΜ concentrations in human primary CD4+T cells.
Molecular Weight

341.38

Formula

C18H15NO4S
CAS No.
Appearance

Solid

SMILES

O=C(C1=C(SC2C(N(C3=CC=CC(C)=C3)C(C2)=O)=O)C=CC=C1)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (146.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9293 mL 14.6464 mL 29.2929 mL
5 mM 0.5859 mL 2.9293 mL 5.8586 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9293 mL 14.6464 mL 29.2929 mL 73.2322 mL
5 mM 0.5859 mL 2.9293 mL 5.8586 mL 14.6464 mL
10 mM 0.2929 mL 1.4646 mL 2.9293 mL 7.3232 mL
15 mM 0.1953 mL 0.9764 mL 1.9529 mL 4.8821 mL
20 mM 0.1465 mL 0.7323 mL 1.4646 mL 3.6616 mL
25 mM 0.1172 mL 0.5859 mL 1.1717 mL 2.9293 mL
30 mM 0.0976 mL 0.4882 mL 0.9764 mL 2.4411 mL
40 mM 0.0732 mL 0.3662 mL 0.7323 mL 1.8308 mL
50 mM 0.0586 mL 0.2929 mL 0.5859 mL 1.4646 mL
60 mM 0.0488 mL 0.2441 mL 0.4882 mL 1.2205 mL
80 mM 0.0366 mL 0.1831 mL 0.3662 mL 0.9154 mL
100 mM 0.0293 mL 0.1465 mL 0.2929 mL 0.7323 mL
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TSLP-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TSLP-IN-1512837-95-5Interleukin RelatedILatopic kerato-conjunctivitischronic obstructive pulmonary diseasethymic stromal lymphopoietin receptorthymic stromal lymphopoietinskin diseasepro-inflammatory cytokineseosinophilic esophagitischronic rhinosinusitisasthmaallergiesInhibitorinhibitorinhibit

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