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PNRI-299 

Cat. No.: HY-15131
Handling Instructions

PNRI-299 is a selective AP-1 transcription inhibitor with an IC50 of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription (up to 200 uM) or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model.

For research use only. We do not sell to patients.

PNRI-299 Chemical Structure

PNRI-299 Chemical Structure

CAS No. : 550368-41-7

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Description

PNRI-299 is a selective AP-1 transcription inhibitor with an IC50 of 20 uM. PNRI-299 is a selective APE/Ref-1 inhibitor. PNRI-299 has no effect on NF-κB transcription (up to 200 uM) or thioredoxin (up to 200 uM). PNRI-299 significantly reduces airway eosinophil infiltration, mucus hypersecretion, edema, and IL-4 levels in a mouse asthma model[1][2][3].

In Vitro

PNRI-299 specifically reacts with Ref-1, inhibits AP-1 transcription, and overexpression of the molecular target. Ref-1 attenuates PNRI-299 inhibition of AP-1 transcription. PNRI-299 interacts with the redox nucleophile Cys-65, to aid in the interpretation of structure activity relationships (SARs)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

PNRI-299 (intranasal; 0.75 or 2.0 mg/kg; 30 min before OVA on days 25-27) reduces the airway inflammatory cell infiltration (arrows) and mucus release in ovalbumin (OVA)-treated (i.p.; 100 μg) female BALB/c mice aged 6-8 wk)[1].
PNRI-299 (3, 10 mg/kg; iv; 5 min before reperfusion) has no significant effect on the translocation of NF-κB in male C57/BL6 mice (8-10 weeks). PNRI-299 has little effect on the inflammatory response that follows intestinal I/R injury[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

401.37

Formula

C₂₁H₁₅N₅O₄

CAS No.

550368-41-7

SMILES

O=C1N2N(C(C(NCC3=CC=CC=C3)=O)=CC(C2)=O)C(N1C4=CC(C#N)=CC=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

PNRI-299PNRI299PNRI 299OthersAP-1transcriptionAPERef-1NF-κBthioredoxinIL-4ovalbuminOVAInhibitorinhibitorinhibit

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PNRI-299
Cat. No.:
HY-15131
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