STAT6-IN-12
STAT6-IN-12 is a potent STAT6 inhibitor with an IC50 of 50 nM. STAT6-IN-12 also inhibits Smad2/3 with an IC50 of 68 nM. STAT6-IN-12 inhibits TGFβ-dependent Smad2/3 signaling pathway, IL-4-dependent STAT6 signaling pathway, and cellular inflammatory responses. STAT6-IN-12 can be used for the research of inflammation.
For research use only. We do not sell to patients.
- CAS No.: 2949393-27-3
- Formula: C18H21ClO6
- Molecular Weight:368.81
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
Smad2/3 68 nM (IC50) |
IL-4 |
STAT6 50 nM (IC50) |
STAT6-IN-12 (compound 27) (24 h) potently inhibits both IL-4-induced STAT6 and TGF-β-induced Smad2/3 signaling pathways in HepG2 cells, with IC50 values of 50 nM and 68 nM, respectively[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
-
CAS No. 2949393-27-3
-
Molecular Weight 368.81
-
Formula C18H21ClO6
-
SMILES
OC1=C(C(/C(C)=C/C[C@H](O)[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz