2. Immunology/Inflammation
  3. Interleukin Related
  4. APG808

APG808 is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis.

For research use only. We do not sell to patients.

APG808

APG808 Chemical Structure

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APG808 Related Antibodies

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22 IL-18

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Description

APG808 is an anti-human IL-4Rα monoclonal antibody. APG808 binds to IL-4Rα, prevents IL-13Rα1/IL-4Rα heterodimer formation, and disrupts IL-13 and IL-4 mediated signaling. APG808 ablates Fc and complement effector functions. APG808 can be used for the research of chronic obstructive pulmonary disease, asthma, atopic dermatitis[1].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
In Vitro

APG808 has a high affinity for human FcRn at pH 6.0, reduced affinity for human FcγRI, FcγRIIIa (F158), and FcγRIIIa (V158), and no detectable binding to human FcγRIIa (H131), FcγRIIa (R131), FcγRIIIb, or C1q[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

APG808 Related Antibodies
Parmacokinetics
Species Dose Route AUC0-inf CL Vss Bioavailability T1/2
Cynomolgus Monkey[1] 25.9 mg/kg s.c. 9.77 × 106 ng·h/mL 2.79 101.80 mL/kg 97.51 % 27.18
Gene ID

3566  [NCBI]

Accession
Target

IL-4Ra/CD124
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[APG808]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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APG808 Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

APG808PR001APG 808APG-808PR 001PR-001Interleukin RelatedILInterleukin-4 receptor-alpha chainasthmachronic obstructive pulmonary diseaseIL-13neonatal Fc receptorIL-4RαIL-13Rα1/IL-4Rα heterodimerIL-4FcRncynomolgus monkeysInhibitorinhibitorinhibit

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