IL-13Rα1
Interleukin-13 receptor alpha 1 (IL-13Rα1, CD213a1) is a 120-145 kDa type I transmembrane glycoprotein of the hematopoietin receptor family that serves as the low-affinity primary binding chain for IL-13. Although IL-13Rα1 alone binds IL-13 weakly, its pairing with IL-4Rα creates the high-affinity type II IL-4/IL-13 receptor, which transduces signals for both IL-13 and IL-4 via JAK1/TYK2-mediated STAT6, IRS-2 and PI3K activation. The receptor is abundantly expressed on non-hematopoietic cells-airway and intestinal epithelium, smooth muscle, fibroblasts and keratinocytes-which explains why IL-13 predominantly evokes tissue remodeling rather than leukocyte activation. IL-13Rα1-mediated signaling drives allergen-induced airway hyperresponsiveness, mucus metaplasia, IgE synthesis, eotaxin production and fibrosis. Dual inhibition of IL-4/IL-13 through this receptor axis (dupilumab targets IL-4Rα) has transformed the treatment of atopic dermatitis, asthma and chronic rhinosinusitis with nasal polyps.
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IL-13Rα1 Recombinant Proteins (7)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
