1. Recombinant Proteins
  2. Cytokines and Growth Factors
  3. Interleukin & Receptors
  4. IL-13 Receptor
  5. IL-13Rα1
  6. IL-13R alpha 1 Protein, Mouse (HEK293, His)

IL-13R alpha 1 Protein, Mouse (HEK293, His)

Cat. No.: HY-P78699
COA Handling Instructions

The IL-13R alpha 1 protein forms a receptor for interleukin-13 when it complexes with IL4RA, activating pathways in allergy response and bronchial asthma. It exhibits ubiquitous expression, including in large intestine adult, colon adult, and 27 other tissues. IL-13R alpha 1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.

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Top Publications Citing Use of Products
  • Biological Activity

  • Technical Parameters

  • Properties

  • Documentation

Description

The IL-13R alpha 1 protein forms a receptor for interleukin-13 when it complexes with IL4RA, activating pathways in allergy response and bronchial asthma. It exhibits ubiquitous expression, including in large intestine adult, colon adult, and 27 other tissues. IL-13R alpha 1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

Background

The IL-13R alpha 1 protein is a transmembrane protein that forms a functional receptor for interleukin-13 when it complexes with interleukin 4 receptor alpha (IL4RA). This pathway is involved in mediating allergy response and is activated during bronchial asthma. The IL-13R alpha 1 protein exhibits ubiquitous expression, including in large intestine adult, colon adult, and 27 other tissues.

Biological Activity

Measured by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells. The ED50 for this effect is 0.690 µg/mL in the presence of 4 ng/mL rmIL-13, corresponding to a specific activity is 1.449×103 units/mg.

  • Measured by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells. The ED50 for this effect is 0.690 µg/mL in the presence of 4 ng/mL rmIL-13. corresponding to a specific activity is 1.449×103 units/mg.
Species

Mouse

Source

HEK293

Tag

C-6*His

Accession

O09030/NP_598751.3 (A26-T340)

Gene ID
Molecular Construction
N-term
IL-13Rα1 (A26-T340)
Accession # O09030/NP_598751
6*His
C-term
Synonyms
IL13RA1; CD213A1; IL-13Ra; NR4; RP13-128O4.2; IL13Rα1
AA Sequence

ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNST

Molecular Weight

47-64 kDa

Purity
  • Greater than 95% as determined by reducing SDS-PAGE.
Appearance

Lyophilized powder.

Formulation

Lyophilized a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Documentation

IL-13R alpha 1 Protein, Mouse (HEK293, His) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

  • Reconstitution Calculator

  • Dilution Calculator

  • Specific Activity Calculator

The reconstitution calculator equation

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration
= ÷

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

The specific activity calculator equation

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)
Unit/mg = 106 ÷ ng/mL

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IL-13R alpha 1 Protein, Mouse (HEK293, His)
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HY-P78699
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