IL-13R alpha 1 Protein, Mouse (HEK293, His)

The IL-13R alpha 1 protein forms a receptor for interleukin-13 when it complexes with IL4RA, activating pathways in allergy response and bronchial asthma. It exhibits ubiquitous expression, including in large intestine adult, colon adult, and 27 other tissues. IL-13R alpha 1 Protein, Mouse (HEK293, His) is the recombinant mouse-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

The IL-13R alpha 1 protein is a transmembrane protein that forms a functional receptor for interleukin-13 when it complexes with interleukin 4 receptor alpha (IL4RA). This pathway is involved in mediating allergy response and is activated during bronchial asthma. The IL-13R alpha 1 protein exhibits ubiquitous expression, including in large intestine adult, colon adult, and 27 other tissues.

Measured by its ability to inhibit IL-13-dependent proliferation of TF-1 human erythroleukemic cells. The ED₅₀ for this effect is 0.690 µg/mL in the presence of 4 ng/mL rmIL-13, corresponding to a specific activity is 1.449×10³ units/mg.

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  Measured by its ability to inhibit IL-13-dependent proliferation of TF‑1 human erythroleukemic cells. The ED₅₀ for this effect is 0.690 µg/mL in the presence of 4 ng/mL rmIL-13. corresponding to a specific activity is 1.449×10³ units/mg.

Mouse

HEK293

C-6*His

O09030/NP_598751.3 (A26-T340)

16164  [NCBI]

Partial

ATEVQPPVTNLSVSVENLCTIIWTWSPPEGASPNCTLRYFSHFDDQQDKKIAPETHRKEELPLDEKICLQVGSQCSANESEKPSPLVKKCISPPEGDPESAVTELKCIWHNLSYMKCSWLPGRNTSPDTHYTLYYWYSSLEKSRQCENIYREGQHIACSFKLTKVEPSFEHQNVQIMVKDNAGKIRPSCKIVSLTSYVKPDPPHIKHLLLKNGALLVQWKNPQNFRSRCLTYEVEVNNTQTDRHNILEVEEDKCQNSESDRNMEGTSCFQLPGVLADAVYTVRVRVKTNKLCFDDNKLWSDWSEAQSIGKEQNST

47-64 kDa

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  ≥ 95%, as determined by reducing SDS-PAGE.

Lyophilized powder.

Lyophilized a 0.22 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.

<1 EU/μg, determined by LAL method.

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Room temperature in continental US; may vary elsewhere.