Copy Link Print Information

IL-13R alpha 1 Protein, Human (HEK293, His)

Customer Review

Based on 1 Customer Validation

The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL-13R alpha 1 Protein, Human (HEK293, His) is the recombinant human-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

For research use only. We do not sell to patients.
  • Species: Human
  • Source: HEK293
  • Storage:
    Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
  • IL-13R alpha 1 Protein, Human (HEK293, His) Product Image
Size
Price
Stock
Quantity
Amount: USD 0.00
Please select quantity
or
or

* Please select Quantity before adding items.

To place orders, for customer services and technical support, please contact: MedChemExpress USA

Tel: 609-228-6898 E-mail: [email protected] [email protected]

Service
Data Download

To place orders, for customer services and technical support, please contact:

609-228-6898
[email protected] [email protected]
Find Your Local Distributor Your local distributor: Hycultec GmbHHycultec
  • Biological Activity
  • Technical Parameters
  • Product Properties
  • Documentation
  • Help & FAQs
Top Publications Citing

Use of MCE Products

Biological Activity

Description

The IL13RA1 protein is critical in immune signaling and binds with low affinity to IL13. It binds to IL4RA to form a functional IL13 receptor for cellular responses. IL-13R alpha 1 Protein, Human (HEK293, His) is the recombinant human-derived IL-13R alpha 1 protein, expressed by HEK293 , with C-6*His labeled tag.

Background

The IL13RA1 protein plays a vital role in immune signaling, exhibiting low-affinity binding to interleukin-13 (IL13). When partnered with IL4RA, it forms a functional receptor for IL13, facilitating the cellular response to this cytokine. Additionally, IL13RA1 serves as an alternate accessory protein alongside IL4RA for interleukin-4 (IL4) signaling, although it cannot replace the function of IL2RG in enhancing interleukin-2 (IL2) binding activity. The interleukin-13 receptor is a complex assembly comprising IL4R, IL13RA1, and possibly other components, indicating the intricate architecture of this signaling system. Moreover, IL13RA1 interacts with TRAF3IP1, suggesting its involvement in diverse cellular processes. Furthermore, IL13RA1 engages in interactions with IL4, underlining its multifaceted role in mediating responses to interleukin signaling pathways.

Technical Parameters

  • Species Human
  • Source HEK293
  • Tag C-6*His
  • Accession

    P78552-1 (G22-T343)

  • Gene ID
    3597  [NCBI]
  • Molecular Construction
    • N-term
    • IL-13Rα1 (G22-T343)
      Accession # P78552-1
    • 6*His
    • C-term
  • Protein Length

    Extracellular Domain

  • Synonyms

    IL13RA1; IL13 Receptor Alpha-1 Chain; Interleukin 13 Receptor Subunit Alpha 1; Cancer/Testis Antigen 19; Interleukin-13 Receptor Subunit Alpha-1; IL-13R Subunit Alpha-1; CD213a1 Antigen; CT19; IL-13Ra; IL-13R-Alpha-1; CD213a1; IL-13RA1; NR4; IL13RA; Inter

  • AA Sequence

    GGGGAAPTETQPPVTNLSVSVENLCTVIWTWNPPEGASSNCSLWYFSHFGDKQDKKIAPETRRSIEVPLNERICLQVGSQCSTNESEKPSILVEKCISPPEGDPESAVTELQCIWHNLSYMKCSWLPGRNTSPDTNYTLYYWHRSLEKIHQCENIFREGQYFGCSFDLTKVKDSSFEQHSVQIMVKDNAGKIKPSFNIVPLTSRVKPDPPHIKNLSFHNDDLYVQWENPQNFISRCLFYEVEVNNSQTETHNVFYVQEAKCENPEFERNVENTSCFMVPGVLPDTLNTVRIRVKTNKLCYEDDKLWSNWSQEMSIGKKRNST

  • Predicted Molecular Mass

    37.7 kDa

  • Molecular Weight

    Approximately 45-65 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.

  • Glycosylation

    Yes

  • Purity

    ≥ 95%, as determined by reducing SDS-PAGE.

Product Properties

Appearance

Lyophilized powder.

Formulation

Lyophilized from a 0.22 μm filtered solution of PBS, pH 7.4.

Endotoxin Level

<1 EU/μg, determined by LAL method.

Reconstitution

It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).

Storage & Stability

Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

Shipping

Room temperature in continental US; may vary elsewhere.

Calculators

Reconstitution Calculator

Volume (to add to vial) = Mass (in vial) ÷ Desired Reconstitution Concentration

Volume (to add to vial) Volume (to add to vial)
=
Mass (in vial) Mass (in vial)
÷
Desired Reconstitution Concentration Desired Reconstitution Concentration
Dilution Calculator

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

Concentration (start) Concentration (start)
×
Volume (start) Volume (start)
=
Concentration (final) Concentration (final)
×
Volume (final) Volume (final)
The Specific Activity Calculator Equation
  • Specific Activity (Unit/mg)
  • Biological Activity (ED50)

Specific Activity (Unit/mg) = 106 ÷ Biological Activity (ED50)

Specific Activity (Unit/mg) Specific Activity (Unit/mg)
Unit/mg
= 106 ÷
Biological Activity (ED50) Biological Activity (ED50)
106 ÷
ng/mL
MOQ
Minimum order quantity
100 mg

Get Quote In-stock

Other size
Get Quote
Please select quantity
Amount: USD 0.00

Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated CTLL-2 mouse cytotoxic T cells. The ED50 this effect is 0.8023 μg/ml, corresponding to a specific activity is 1246.42 units/mg.

Assay Types
  • IL-13R alpha 1 Protein, Human (HEK293, His) Product Image
    1/16
  • IL-13R alpha 1 Protein, Human (HEK293, His) Product Image