IL13RA1 - interleukin 13 receptor subunit alpha 1 Gene

Also Known as NR4; CT19; CD213A1; IL-13Ra

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 3597

About IL13RA1

Cytogenetic location: Xq24 Genomic coordinates (GRCh38): X:118,727,606-118,805,228 (from NCBI)

This gene has 4 transcripts (splice variants), 418 orthologues and 23 paralogues. Ubiquitous expression in colon (RPKM 22.2), liver (RPKM 22.1) and 25 other tissues.

Summary

The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase Tyk2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]

IL13RA1 Products (1)

mRNA Protein Name
NM_001560.3 NP_001551.1 interleukin-13 receptor subunit alpha-1 precursor

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
12935900 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

IL13RA1 Protein Structure

IL6Ra-bind

IL6Ra-bind: Interleukin-6 receptor alpha chain, binding (128 - 223)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 427 a.a.
Protein Preferred Names Protein Names

interleukin-13 receptor subunit alpha-1

  • CD213a1 antigen

IL13RA1 Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Verweise
Intra
IL13RA1 P78552 IL13 Homo sapiens P35225
ITC
18243101
Intra
IL13RA1 P78552 IL13 Homo sapiens P35225
X-Ray Diffraction
18243101
Intra
IL13RA1 P78552 IL4 Homo sapiens P05112
ITC
18243101
Intra
IL13RA1 P78552 IL4 Homo sapiens P05112
X-Ray Diffraction
18243101
Intra
IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Y3H
12935900
Intra
IL13RA1 P78552 TRAF3IP1 Homo sapiens Q8TDR0
Anti Tag CoIP
12935900
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant IL13RA1 Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P72594 IL-13R alpha 1 Protein, Human (HEK293, His) P78552-1 (G22-T343) ≥ 95%, as determined by reducing SDS-PAGE.
HY-P78163 IL-13R alpha 1 Protein, Human (Biotinylated, HEK293, His-Avi) P78552-1 (A27-T343) ≥ 95%, as determined by Bis-Tris PAGE.

IL13RA1 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P81632 IL-13 Receptor alpha 1 Antibody (YA1377) FC, ELISA Human
HY-P81879 IL-13 Receptor alpha 1 Antibody (YA1624) WB Human
HY-P84441 IL-13 Receptor alpha 1 Antibody (YA4138) WB, FC, ELISA Human
HY-P84441A IL-13 Receptor alpha 1 Antibody (YA4138)(PBS only) WB, FC, ELISA Human

Related Diseases

Diseases Alias
Monofixation Syndrome
Interstitial Lung Disease

  • Ild

  • Lung Diseases, Interstitial

  • Lung Diseases Interstitial

  • Interstitial Lung Diseases
Asthma

  • Chronic Obstructive Asthma

  • Asthma, Diminished Response To Antileukotriene Treatment In

  • Bronchial Hyperreactivity

  • Asthma, Susceptibility To

  • Asthma, Bronchial

  • Asthma, Protection Against

  • Asthma, Nocturnal, Susceptibility To

  • Nocturnal Asthma

  • Asthma-Related Traits

  • Asthma-Related Traits, Susceptibility To

  • Asthma, Nocturnal

  • Chronic Obstructive Asthma With Acute Exacerbation

  • Chronic Obstructive Asthma With Status Asthmaticus

  • Exercise Induced Asthma

  • Exercise-Induced Asthma

  • Bronchial Asthma

  • Asthma, Exercise-Induced

  • Idiosyncratic Asthma

  • Unspecified Asthma With Acute Exacerbation

  • Asthma, Unspecified, With Stated Status Asthmaticus

  • Status Asthmaticus Nos

  • Acute Severe Asthma

  • Acute Severe Bronchial Asthma

  • Status Asthma

  • Status Post Asthmaticus
Syndromic X-Linked Intellectual Disability Cabezas Type

  • Cabezas Syndrome

  • Syndromic X-Linked Mental Retardation 15

  • Mental Retardation, X-Linked, Syndromic 15

  • Mrss

  • Mrxs15

  • Mrxsc

  • X-Linked Mental Retardation With Short Stature

  • X-Linked Mental Retardation With Short Stature, Hypogonadism, And Abnormal Gait

  • Mental Retardation, X-Linked, With Short Stature

  • Mental Retardation, X-Linked, With Short Stature, Hypogonadism, And Abnormal Gait
High Grade Glioma

  • Malignant Glioma

  • Glial Cell Tumor

  • Glioma, Malignant

  • Malignant Neuroglial Tumor

  • Neuroglial Tumor

  • Glioma

  • Malignant Gliomas
Brain Cancer

  • Adult Brain Tumor

  • Malignant Neoplasm Of Brain

  • Brain Neoplasms

  • Brain Neoplasm

  • Neoplasm Of Brain

  • Primary Malignant Neoplasm Of Brain

  • Brain Tumors

  • Adult Malignant Brain Neoplasm

  • Brain Neoplasm, Adult

  • Bt - Brain Tumour

  • Malignant Brain Tumour

  • Malignant Primary Brain Neoplasm

  • Malignant Primary Brain Tumor

  • Malignant Tumor Of Adult Brain

  • Malignant Tumor Of Brain

  • Primary Brain Neoplasm

  • Primary Brain Tumor

  • Tumor Of The Brain

  • Brain Tumor, Adult

  • Brain Tumor Primary

  • Malignant Primary Brain Tumors

  • Primary Brain Tumors

  • Cancer, Brain

  • Brain Tumor, Primary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Art. -Nr. Produktname Wirkung
Reinheit Phase
HY-P99870 Eblasakimab ≥99.0% Phase 2

Pre-clinical Phase

Bioactive Molecules (4)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS06688 IL13RA1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-174638 Human IL13RA1 mRNA / Unkown
HY-RS19279 Il13ra1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25769 Il13ra1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Rattus norvegicus IL13RA1 RGD RGD:628741
Mus musculus IL13RA1 MGD MGI:105052
Bos taurus IL13RA1 VGNC VGNC:55053
Felis catus IL13RA1 VGNC VGNC:67758
Canis familiaris IL13RA1 VGNC VGNC:41937
Others IL13RA1 NCBI