1. JAK/STAT Signaling
    Stem Cell/Wnt
  2. STAT
  3. YM-341619

YM-341619 (Synonyms: AS1617612)

Cat. No.: HY-134771
Handling Instructions

YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma.

For research use only. We do not sell to patients.

YM-341619 Chemical Structure

YM-341619 Chemical Structure

CAS No. : 643082-52-4

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Description

YM-341619 (AS1617612) is a potent and orally active STAT6 inhibitor with an IC50 of 0.70 nM. YM-341619 inhibits Th2 differentiation in mouse spleen T cells induced by IL-4 (IC50=0.28 nM) without affecting Th1 cell differentiation[1]. YM-341619 is a promising compound for the the research of allergic diseases, such as allergic asthma[2].

IC50 & Target[1]

STAT6

0.70 nM (IC50)

In Vitro

YM-341619 (0.1-100 nM; pretreatment 30 min before IL-4) inhibits IL-4-increased STAT6 luciferase gene activity in a concentration dependent manner, exhibiting an IC50 value of 1.5 nM in FW4 cells[2].
YM-341619 (0.1-10 nM; pretreatment 30 min before IL-4) concentration-dependently decreases the production of IL-4 and the expression of GATA-3 mRNA in T cells cultured with IL-4. And it has no effects on the production of IFN-γ or the expression of T-bet (a Th1 transcription factor) mRNA in T cells cultured with IL-12[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR[2]

Cell Line: T cells
Concentration: 0.1 nM, 1 nM, 10 nM
Incubation Time: Pretreatment 30 min before IL-4, then IL-4 treated for 16 hours
Result: Decreased IL-4 and GATA-3 mRNA expression.
In Vivo

YM-341619 (intravenous injection; 1 mg/kg) exhibits CLtot, t1/2, Vd values of 36.1 mL/min/kg, 1.0 hour, 3117 mL/kg, respectively. And it exhibits Cmax, Tmax, AUC, and F% values of 80 ng/mL, 0.5h, 114 ng h/mL and 25%, respectively in 8-week-old female balb/c mice[1].
YM-341619 (oral administration; 0.003-0.03 mg/kg) suppresses the IgE level in a dose-dependent manner, but not the IgG2a level, and the ED50 value of YM-341619 for the suppression of IgE production is 0.026 mg/kg. YM-341619 tends to decrease IL-4 production and decrease IL-13 production in a dose-dependent manner (both 57%), but does not affect IFN-γ production in DNP-Ascaris-sensitized rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DNP-Ascaris-sensitized rats[1]
Dosage: 0.003-0.03 mg/kg
Administration: Oral administration; 0.003-0.03 mg/kg
Result: Suppressed IL-4 and IL-13 production in splenocytes derived from DNP-ascaris-sensitized rats without reducing IFN-γ production.
Molecular Weight

458.44

Formula

C₂₂H₂₁F₃N₆O₂

CAS No.

643082-52-4

SMILES

O=C(C1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1NCC4=C(F)C=CC(F)=C4F)N

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

YM-341619AS1617612YM341619YM 341619AS 1617612AS-1617612STATallergic diseaseasthmaT cellsTh2differentiationairway inflammationInhibitorinhibitorinhibit

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YM-341619
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