1. JAK/STAT Signaling
    Stem Cell/Wnt
    Metabolic Enzyme/Protease
  2. STAT
    Cytochrome P450
  3. AS1810722

AS1810722 

Cat. No.: HY-134772
Handling Instructions

AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722 has the potential for allergic diseases such as asthma and atopic diseases.

For research use only. We do not sell to patients.

AS1810722 Chemical Structure

AS1810722 Chemical Structure

CAS No. : 909561-15-5

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Description

AS1810722 is an orally active and potent STAT6 inhibitor with an IC50 of 1.9 nM. AS1810722 shows a good profile of CYP3A4 inhibition. AS1810722 has the potential for allergic diseases such as asthma and atopic diseases[1].

IC50 & Target[1]

STAT6

1.9 nM (IC50)

CYP3A4

 

In Vitro

AS1810722 (compound 24) inhibits production of IL-4 with an IC50 of 2.4 nM, but shows no effect on production of IFN-γ[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

AS1810722 (compound 24) suppress eosinophil infiltration in the lung in a dose-dependent manner in an antigen-induced mouse asthmatic model[1].
AS1810722 inhibits in vitro Th2 differentiation with an IC50 of 2.4 nM without affecting type 1 helper T (Th1) cell differentiation and eosinophil infiltration in an antigen-induced mouse asthmatic model after oral administration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c mice asthmatic model by intraperitoneal injection of OVA-containing aluminum hydroxide gel[1]
Dosage: 0.03-0.3 mg/kg
Administration: Orally; 30 min before, and 24 and 48 h after OVA exposure
Result: Suppressed eosinophil infiltration in the lung in a dose-dependent manner.
Molecular Weight

477.51

Formula

C₂₅H₂₅F₂N₇O

CAS No.

909561-15-5

SMILES

O=C(N)CN1CCN(C2=CC=C(NC3=NC=C4C(N(CC5=CC(F)=CC(F)=C5)C=C4)=N3)C=C2)CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
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Keywords:

AS1810722AS 1810722AS-1810722STATCytochrome P450CYPsorallyallergicasthmaIL-4IFN-γeosinophilinfiltrationInhibitorinhibitorinhibit

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AS1810722
Cat. No.:
HY-134772
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