IL-4-inhibitor-1
Based on 3 publication(s) in Google Scholar
IL-4-inhibitor-1 (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 µM.
For research use only. We do not sell to patients.
- Purity: 98.04%
- CAS No.: 1332184-63-0
- Formula: C18H12FN3O2
- Molecular Weight:321.31
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Storage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) IL-4-inhibitor-1
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Customer Validation & Images
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Histological Imaging/Staining
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In Vivo Efficacy Study
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WB
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IF
Biological Activity
EC50: 1.81 µM (IL-4)[1].
IL-4-inhibitor-1 (compound 52) displays low micromolar affinity and exhibits functional disruption of type II IL-4 binding in a cellular context[1].
IL-4-inhibitor-1 (compound 52) exhibits dose-dependent reduction in pSTAT-6 levels with an EC50 value of 3.1 µM, but did not affect the levels of STAT-6[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1332184-63-0
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Appearance Solid
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Molecular Weight 321.31
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Formula C18H12FN3O2
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Color Light yellow to yellow
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SMILES
N#CC1=C(C2=CC=C(O)C(O)=C2)C=C(C3=CC=C(F)C=C3)N=C1N
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Publications (3)
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Journal Impact Factor
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Most Recent
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CNS Neurosci Ther
IL-4-JAK1-STAT6 Pathway Mediates Electroacupuncture's Effect on Microglial M2 Polarization to Treat Inflammatory Bowel Disease With Comorbid Depression. [Abstract]2025 Aug;31(8):e70572. PMID: 40823702
IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572. [Abstract]
HE staining of colon tissue treated with IL‐4 inhibitor (10 mg/kg, i.p.).
IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572. [Abstract]
Colon length in the MOD, IL‐4 inhibitor, and EA + IL‐4 inhibitor (10 mg/kg, i.p.) groups was significantly shortened.
IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572. [Abstract]
Protein expression levels of IL‐1β, IL‐4, IL‐10, and TGF‐β1 in colon tissue treated with IL‐4 inhibitor (10 mg/kg, i.p.).
IL-4-inhibitor-1 purchased from MedChemExpress. Usage Cited in: CNS Neurosci Ther. 2025 Aug;31(8):e70572. [Abstract]
Expression of Iba‐1 and CD206 in the hippocampal region of mice treated with IL‐4 inhibitor (10 mg/kg, i.p.).
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Oral Dis
Stretched Vascular Endothelial Cells Polarized Neutrophils to N2 Type via TRPC1-IL13-STAT3 Axis. [Abstract]2025 Mar;31(3):918-927. PMID: 39462789 -
Mol Pain
EXPRESS: CB2 receptor agonist AM1241 regulating the polarization of microglia reduces morphine tolerance through IL-4/STAT6 pathway. [Abstract]2025 Aug 18:17448069251374281. PMID: 40823889
Solvent & Solubility
DMSO : 100 mg/mL (311.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (273 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.1123 mL | 15.5613 mL | 31.1226 mL | 77.8065 mL |
| 5 mM | 0.6225 mL | 3.1123 mL | 6.2245 mL | 15.5613 mL | |
| 10 mM | 0.3112 mL | 1.5561 mL | 3.1123 mL | 7.7806 mL | |
| 15 mM | 0.2075 mL | 1.0374 mL | 2.0748 mL | 5.1871 mL | |
| 20 mM | 0.1556 mL | 0.7781 mL | 1.5561 mL | 3.8903 mL | |
| 25 mM | 0.1245 mL | 0.6225 mL | 1.2449 mL | 3.1123 mL | |
| 30 mM | 0.1037 mL | 0.5187 mL | 1.0374 mL | 2.5935 mL | |
| 40 mM | 0.0778 mL | 0.3890 mL | 0.7781 mL | 1.9452 mL | |
| 50 mM | 0.0622 mL | 0.3112 mL | 0.6225 mL | 1.5561 mL | |
| 60 mM | 0.0519 mL | 0.2594 mL | 0.5187 mL | 1.2968 mL | |
| 80 mM | 0.0389 mL | 0.1945 mL | 0.3890 mL | 0.9726 mL | |
| 100 mM | 0.0311 mL | 0.1556 mL | 0.3112 mL | 0.7781 mL |
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