(14S,15R)-14-Deoxyoxacyclododecindione
(14S,15R)-14-Deoxyoxacyclododecindione (Compound 3) acts as an inhibitor of TGF-β-dependent Smad2/3 and IL-4-dependent STAT6, with IC50 values of 90 nM and 20 nM, respectively. (14S,15R)-14-deoxyoxacyclododecindione is a potent IL-4 inhibitor with an IC50
value of 20 nM. (14S,15R)-14-Deoxyoxacyclododecindione is applicable to the research of chronic inflammation and fibrotic diseases.
For research use only. We do not sell to patients.
- CAS No.: 1899061-36-9
- Formula: C18H21ClO5
- Molecular Weight:352.81
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
value of 20 nM. (14S,15R)-14-Deoxyoxacyclododecindione is applicable to the research of chronic inflammation and fibrotic diseases[1].
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IL-4 20 nM (IC50) |
STAT6 20 nM (IC50) |
Smad2/3 90 nM (IC50) |
(14S,15R)-14-deoxyoxacyclododecindione potently inhibits IL-4-dependent STAT6 signaling with an IC50 of 20 ± 1 nM and TGF-β-dependent Smad2/3 signaling with an IC50 of 90 ± 10 nM in transiently transfected HepG2 cells[1].
(14S,15R)-14-deoxyoxacyclododecindione is a potent IL-4 inhibitor with an IC50
value of 20 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1899061-36-9
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Molecular Weight 352.81
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Formula C18H21ClO5
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SMILES
OC1=C(C(/C(C)=C/CC[C@H](C)[C@@H](C)OC2=O)=O)C(C2)=C(Cl)C(O)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
(14S,15R)-14-Deoxyoxacyclododecindione Related Classifications
HY-162404 Related Classifications
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