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Cat. No.: HY-184822

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STAT6-IN-14

STAT6-IN-14 is a STAT6 inhibitor that blocks the binding of STAT6-pIL-4Rα, with an IC₅₀ of 1.20 μM. STAT6-IN-14 can inhibit IL-4-induced STAT6 transcriptional activity in STAT6-HEK293 cells. STAT6-IN-14 can be used for research on allergic diseases and inflammation.

For research use only. We do not sell to patients.

CAS No.: 3033741-74-8
Formula: C₂₉H₂₄F₄N₆O₃
Molecular Weight:580.53

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

STAT6-IN-14 Chemical Structure

CAS No.: 3033741-74-8

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
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Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

STAT6

1.2 μM (IC₅₀)

All STAT Isoforms :

In Vitro

STAT6-IN-14 (Compound 39) inhibits the binding of human STAT6 to phosphorylated IL-4 receptor α (pIL-4Rα) in a cell‑free system, with an IC₅₀of 1.20 μM (30 min pre‑incubation + 30 min fluorescence polarization detection)^[1].
STAT6-IN-14 (0.1-1 μM; 1 h pre‑incubation + 6 h IL‑4 stimulation) inhibits STAT6‑mediated transcriptional activity in HEK293 cells overexpressing human STAT6, with inhibition rates of 99% at 1 μM and 84% at 0.1 μM, and no significant cytotoxicity is observed^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

HEK293 cells
Concentration:

0.1 μM
Incubation Time:

1 h pre‑incubation + 6 h IL‑4 stimulation
Result:

Inhibited STAT6-mediated transcriptional activity with an inhibition rate of 84%, and the cell viability was > 70%, indicating no significant cytotoxicity at this concentration.

Chemical Information

CAS No. 3033741-74-8
Molecular Weight 580.53
Formula C₂₉H₂₄F₄N₆O₃
SMILES

O=C(C1=CC(NC(C2=CC(C(F)(F)F)=CC3=C2N(CC)C(C4=CC=C(N5C(N(C)N=C5C)=O)C=C4)=C3)=O)=CC=C1F)N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Sumikawa, Y., et al. "Fused Ring Compound and Pharmaceutical Containing the Same." World Intellectual Property Organization, 4 Apr. 2024, WO 2024/071439 A1.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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STAT6-IN-14

All STAT Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

STAT6-IN-14 Related Classifications

HY-184822 Related Classifications