Tilrekimig  (Synonyms: PF-07275315)

Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis^[1][2].

immunoglobulin (L-kappa-H-gamma1 (_L-VH-G1(CH1-h))_Lkappa)_(H-gamma1_L-lambda2)

Human

Tilrekimig (TAVO101 × IL4R-dupi) effectively blocks the signaling cascades driven by TSLP, IL-4 and IL-13, and neutralizes TSLP-driven CD4+ T cell proliferation as well as IL-4- and IL-13-driven TF-1 cell proliferation^[2].
Tilrekimig reduces the release of CCL17 in CD14⁺ monocytes activated by LPS (HY-D1056), TSLP and IL-4, and decreases the allergen-induced release of CCL26 and IL-5 in the co-culture system of PBMC, MRC-5 and A549 cells^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Tilrekimig (TAVO101 x IL4R-dupi) (10 mg/kg, i.p., once weekly for 2 consecutive weeks) broadly controls allergic inflammation in mice in a TSLP/OVA-induced asthma model^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3565  [NCBI] & 3596  [NCBI]

P05112 & P35225

ELISA, FACS, Functional assay

Unconjugated

The product can be reconstituted/diluted with sterile PBS or saline.

193.681 kDa

2981469-90-1

Liquid

Colorless to off-white

[Tilrekimig]

Shipping with dry ice.

Please refer to the lot-specific COA for specific buffer information.

Please store the product under the recommended conditions in the Certificate of Analysis.

• 
  Fab-kappa_IgG1-kappa-lambda_disulfide

• 
  Loaded Tilrekimig on ProA biosensor, can bind HY-P70764 IL-4 Protein, Human (HEK293, His) with an affinity constant of 3.074E-10 M as determined in BLI assay.
• 
  Loaded Tilrekimig on ProA biosensor, can bind HY-P70568 IL-13 Protein, Human (HEK293, His) with an affinity constant of 1.917E-09 M as determined in BLI assay.
• 
  Loaded Tilrekimig on ProA biosensor, can bind HY-P70818 TSLP Protein, Human (HEK293, His) with an affinity constant of 1.060E-09 M as determined in BLI assay.

• [1]. Yu M, et al. A Bispecific Antibody Blocking Both TSLP and IL-4Rα for the Treatment of Allergic Inflammatory Diseases. Cells. 2025 Nov 7;14(22):1747.
  

  [2]. Brinkmann U, et al. The making of multispecific immunoglobulins - a clinical perspective. MAbs. 2026;18(1):2613548.  [Content Brief]