Tilrekimig
Based on 1 Customer Validation
Tilrekimig (PF-07275315) is a monoclonal antibody targeting human interleukin-4 (IL-4), interleukin-13 (IL-13) and thymic stromal lymphopoietin (TSLP). Tilrekimig can be used in the research of allergic and inflammatory diseases, such as asthma and atopic dermatitis.
For research use only. We do not sell to patients.
- Purity: 96%
- CAS No.: 2981469-90-1
- Molecular Weight:193.681 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
immunoglobulin (L-kappa-H-gamma1 (_L-VH-G1(CH1-h))_Lkappa)_(H-gamma1_L-lambda2)
Human
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IL-4 |
IL-13 |
Tilrekimig effectively blocks the signaling cascades driven by TSLP, IL-4 and IL-13, and neutralizes TSLP-driven CD4+ T cell proliferation as well as IL-4- and IL-13-driven TF-1 cell proliferation[2].
Tilrekimig reduces the release of CCL17 in CD14+ monocytes activated by LPS (HY-D1056), TSLP and IL-4, and decreases the allergen-induced release of CCL26 and IL-5 in the co-culture system of PBMC, MRC-5 and A549 cells[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:hIL4/hIL4RA/hTSLP/hTSLPR plus humanized transgenic mice[2]
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Dosage:10 mg/kg
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Administration:i.p., once weekly for 2 consecutive weeks
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Result:Showed comprehensive inhibitory effects on multiple key asthma markers, including serum IgE, eosinophil infiltration in BALF, lung tissue inflammation, and mucus secretion.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Fab-kappa_IgG1-kappa-lambda_disulfide
ELISA, FACS, Functional assay
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Loaded Tilrekimig on ProA biosensor, can bind HY-P70764 IL-4 Protein, Human (HEK293, His) with an affinity constant of 3.074E-10 M as determined in BLI assay. -
Loaded Tilrekimig on ProA biosensor, can bind HY-P70568 IL-13 Protein, Human (HEK293, His) with an affinity constant of 1.917E-09 M as determined in BLI assay. -
Loaded Tilrekimig on ProA biosensor, can bind HY-P70818 TSLP Protein, Human (HEK293, His) with an affinity constant of 1.060E-09 M as determined in BLI assay.
Chemical Information
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CAS No. 2981469-90-1
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Appearance Liquid
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Molecular Weight 193.681 kDa
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Color Colorless to off-white
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SMILES
[Tilrekimig]
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Synonyms
PF-07275315
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Shipping
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Data Sheet (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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