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Cat. No.: HY-P99870

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Eblasakimab

Name: Eblasakimab
Brand: MedChemExpress
SKU: HY-P99870
Price: 300.00 USD
Availability: InStock
Rating: 5 (1 reviews)

(Synonyms: ASLAN004; CSL-334; MK-6105)

고객리뷰

Based on 1 Customer Validation

Eblasakimab (ASLAN004) is a fully human monoclonal antibody that binds with high affinity to IL-13Rα1 (binds to IL-13Rα1 with a K_d of 453 pM). Eblasakimab reduces neuronal responses to IL-4, IL-13, and their combination. Eblasakimab can be used in research on atopic dermatitis.

연구목적의 판매만을 진행합니다. 환자를 대상으로 한 판매는 하지 않습니다.

Purity : ≥99.0%
CAS No.: 2445460-16-0
분자량:143.86 kDa

보관:

Shipping with dry ice

Please store the product under the recommended conditions in the Certificate of Analysis.

Eblasakimab Chemical Structure

CAS No.: 2445460-16-0

사이즈

가격

재고

수량

Amount: USD 0.00

* 장바구니에 담기 전 물품의 수량을 선택해 주십시오.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

제품 설명

Isotype

Human IgG4 kappa

Recommend Isotype Controls

Human IgG4 (S228P) kappa, Isotype Control

Species Reactivity

Human

IC₅₀ & Target

^[5]^[1]

IL-13Rα1

453 pM (Kd)

IL-4

IL-13

All Interleukin Related Isoforms :

In Vitro

Cytokines & Chemokines

Eblasakimab significantly reduces neuronal responses to IL-4, IL-13, and their combination by more than 40%^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

TPA/Croton Oil Ear Edema and Dermatitis

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991			2011-05	PHASE1

Gene ID

3597 [NCBI]

Accession

P78552-1

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Human IgG4 kappa

신청

ELISA, FACS, Functional assay

Chemical Information

CAS No. 2445460-16-0
Appearance Liquid
분자량 143.86 kDa
Color Colorless to light yellow
SMILES

[Eblasakimab]
Synonyms

ASLAN004; CSL-334; MK-6105
선적

Shipping with dry ice.
Formulation

Please refer to the lot-specific COA for specific buffer information.
보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (267 KB)
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Inhibitory Antibodies User Guide (603 KB)

References

[1]. Jin L, et al. LB1037 Aberrant regulation of protein translation controlled by eukaryotic initiation factor 4F (eIF4F) in the pathogenesis of hidradenitis suppurativa (HS) and associated cutaneous squamous cell carcinoma (cSCC). Journal of Investigative Dermatology. 2022 Aug 1;142(8):B37.

[2]. Reddy SV, et al. LB1751 Downstream effects of IL-13Rα1 blockade on type 2 inflammation and Th1 immune axis activation in atopic dermatitis. Journal of Investigative Dermatology. 2023 Sep 1;143(9):B26.

[3]. Okamoto T, et al. LB1036 Artificial intelligence for the automated assessment of psoriasis severity. Journal of Investigative Dermatology. 2022 Aug 1;142(8):B37.

[4]. Cevikbas F, et al. Eblasakimab, a novel IL-13 receptor alpha 1 monoclonal antibody, blocks STAT6 phosphorylation with low dose in human volunteers. Clinical immunology (Orlando, Fla.). 2023 Aug;253:109677.

[5]. Veverka KA, et al. Safety and efficacy of eblasakimab, an interleukin 13 receptor α1 monoclonal antibody, in adults with moderate-to-severe atopic dermatitis: A phase 1b, multiple-ascending dose study. J Am Acad Dermatol. 2024 Mar;90(3):504-511.

Calculators

몰농도 계산기

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

농도 희석 계산기

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

MOQ

Minimum order quantity

100 mg

견적 받기 해외재고보유

Other size

견적 받기

Amount: USD 0.00

Biological Activity
- 제품 설명
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- IC₅₀ & Target
- In Vitro
- Clinical Trial
- Gene ID
- Accession
- Conjugated
- Reconsititution
- Format
- 신청
Chemical Information
순도&문서
References

상품명:
Cat. No.:
수량:
MCE Japan Authorized Agent:

상품명:
CAS No.:
Species:
Purity:
수량:

Eblasakimab

All Interleukin Related Isoforms