2. Immunology/Inflammation Anti-infection
  3. CD1 IFNAR Interleukin Related Bacterial Influenza Virus
  4. Glycolipid C34

Glycolipid C34, α-GalCer (HY-102022) analog, is a CD1d-binding glycolipid antinfection agent. Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4. Glycolipid C34 promotes clearance of bacterial infections in murine models and enhances protective immunity against viral infections. Glycolipid C34 can be used for the research of bacterial infection, viral infection.

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Glycolipid C34

Glycolipid C34 Chemical Structure

CAS No. : 1204401-08-0

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Glycolipid C34 Related Antibodies

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Description

Glycolipid C34, α-GalCer (HY-102022) analog, is a CD1d-binding glycolipid antinfection agent. Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4. Glycolipid C34 promotes clearance of bacterial infections in murine models and enhances protective immunity against viral infections. Glycolipid C34 can be used for the research of bacterial infection, viral infection[1].

IC50 & Target[1]

CD1d

 

IL-4

 

In Vitro

Glycolipid C34 mediates invariant natural killer T cell activation and increases the secretion of IFN-γ and IL-4 by binding CD1d[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Glycolipid C34 Related Antibodies
In Vivo

Glycolipid C34 (50 μg/kg; i.p.; single dose; 3 hours post-infection) significantly reduces liver bacterial loads in Sphingomonas capsulata-infected C57BL/6 mice[1].
Glycolipid C34 (150 μg/kg; i.p.; single dose; 3 hours post-infection) significantly reduces bacterial burden in S. aureus Xen29 thigh-infected BALB/c mice[1].
Glycolipid C34 (150 μg/kg; i.p.; single dose; 0-6 h post-infection) significantly reduces bacterial burden in S. aureus Xen29 thigh-infected BALB/c mice at 0 h, with delayed administration (6 hours post-infection) showing reduced efficacy[1].
Glycolipid C34 (1 μg; i.p.; two doses; 1 day pre- and 1 day post-challenge) increases survival of JEV- and WSN-infected C57BL/6 mice, with protection dependent on intact innate and adaptive immune components[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (female, 6 to 8 weeks old; Sphingomonas capsulata infection model)[1]
Dosage: 50 μg/kg
Administration: i.p.; single dose; 3 hours post-infection
Result: Significantly reduced liver bacterial CFU counts compared to vehicle control (P < 0.01), with mean CFU counts lower than those seen with α-GalCer treatment.
Animal Model: BALB/c (female; Staphylococcus aureus Xen29 deep thigh wound infection model)[1]
Dosage: 150 μg/kg
Administration: i.p.; single dose; 0, 3, 6 hours post-infection
Result: Significantly reduced relative luminescence units (a marker of bacterial burden) compared to vehicle control (P < 0.05), with a greater degree of bacterial clearance than seen with α-GalCer treatment.
Animal Model: C57BL/6 (7 weeks old; Japanese encephalitis virus RP-9 strain and influenza virus WSN infection model)[1]
Dosage: 1 μg
Administration: i.p.; two doses; 1 day pre-challenge and 1 day post-challenge
Result: Significantly prolonged survival compared to vehicle control.
Molecular Weight

834.11

Formula

C47H76FNO10
CAS No.
SMILES

CCCCCCCCCCCCCC[C@H]([C@H]([C@@H](NC(CCCCCCCCCCC1=CC=C(C=C1)OC2=CC=C(C=C2)F)=O)CO[C@H]3O[C@H](CO)[C@H](O)[C@H](O)[C@H]3O)O)O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Glycolipid C34 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Glycolipid C341204401-08-0Glycolipid C 34Glycolipid C-34CD1IFNARInterleukin RelatedBacterialInfluenza VirusInterferon-α/β receptorInterferon-alpha/beta receptor ILStat-1Sphingomonas capsulatamurine modelsJapanese encephalitis virusCD1dCD8α chainC57BL/6 miceT-helper-cell 1 cytokine responseimmunoglobulin μ chaininvariant natural killer T cellInhibitorinhibitorinhibit

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