IL4RPep-1
Based on 1 publication(s) in Google Scholar
IL4RPep-1 is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors.
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- CAS No.: 1900734-29-3
- 화학식: C44H80N20O13S2
- 분자량:1161.36
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보관:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocol
- 순도&문서
- References
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Help & FAQs
Publications Citing Use of MedChemExpress (MCE) IL4RPep-1
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Biological Activity
제품 설명
IC50 & Target
[1]|
IL-4Rα/IL4R/CD124 |
In Vitro
IL4RPep-1 (biotin-labeled IL4RPep-1; 1-80 μM; 1 h) binds to H226 squamous cell lung cancer cells with high IL-4R expression, with a dissociation constant Kd of 6.5 μM, and its binding affinity is significantly higher than that to H460 large cell lung cancer cells with low IL-4R expression (Kd = 51.9 μM)[1].
IL4RPep-1 (100 μg IL4RPep-1; 0-24 h) remains stable in mouse serum at 37 °C for at least 4 h, and most of the peptide stays intact even after 24 h of incubation[1].
IL4RPep-1 (10 μM; 1 h) preferentially binds to TNF-α-activated HUVEC with upregulated IL-4R expression, compared with untreated human umbilical vein endothelial cells (HUVEC)[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
In Vivo
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 1900734-29-3
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분자량 1161.36
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화학식 C44H80N20O13S2
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Sequence
Cys-Arg-Lys-Arg-Leu-Asp-Arg-Asn-Cys (Disulfide bridge: Cys1-Cys9)
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Sequence Shortening
CRKRLDRNC (Disulfide bridge: Cys1-Cys9)
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선적
Room temperature in continental US; may vary elsewhere.
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보관
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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J Control Release
Nanoprodrug targeting tumor-associated intracellular bacteria enhances colorectal cancer immunotherapy. [Abstract]2026 Feb 10:390:114512. PMID: 41360332
Protocol
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RNA extraction experimental
By lysing cells, releasing RNA, and removing impurities such as proteins and DNA, high-purity RNA products are finally obtained. The commonly used traditional method is the guanidine isothiocyanate/phenol/chloroform method (Trizol), which is suitable for a variety of animal materials including animal tissues, microorganisms, cultured cells, etc., and most plant materials.
순도&문서
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
IL4RPep-1 Related Classifications
HY-P11143 Related Classifications
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