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Cat. No.: HY-P11143

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IL4RPep-1

1 Cited Publications

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Based on 1 publication(s) in Google Scholar

IL4RPep-1 is an interleukin-4 receptor (IL-4R) binding agent. IL4RPep-1 preferentially binds to cells with high levels of IL-4R expression compared to those with low levels of expression. IL4RPep-1-labeled liposomes containing Doxorubicin (HY-15142A) are internalized by cells more efficiently. IL4RPep-1-labeled liposomes accumulate more effectively within H226 tumors.

For research use only. We do not sell to patients.

CAS No.: 1900734-29-3
Formula: C₄₄H₈₀N₂₀O₁₃S₂
Molecular Weight:1161.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

IL4RPep-1 Chemical Structure

CAS No.: 1900734-29-3

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (1)
Purity & Documentation
References
Calculators
Help & FAQs
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

IL-4Rα/IL4R/CD124

All Interleukin Related Isoforms :

In Vitro

IL4RPep-1 (biotin-labeled IL4RPep-1; 1-80 μM; 1 h) binds to H226 squamous cell lung cancer cells with high IL-4R expression, with a dissociation constant K_d of 6.5 μM, and its binding affinity is significantly higher than that to H460 large cell lung cancer cells with low IL-4R expression (K_d = 51.9 μM)^[1].
IL4RPep-1 (100 μg IL4RPep-1; 0-24 h) remains stable in mouse serum at 37 °C for at least 4 h, and most of the peptide stays intact even after 24 h of incubation^[1].
IL4RPep-1 (10 μM; 1 h) preferentially binds to TNF-α-activated HUVEC with upregulated IL-4R expression, compared with untreated human umbilical vein endothelial cells (HUVEC)^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

IL4RPep-1-labeled doxorubicin-loaded liposomes (doxorubicin equivalent dose of 1 mg/kg; intravenous injection; twice weekly for a total of 7 times) significantly inhibit the growth of H226 lung cancer xenografts compared with the untreated control group, free doxorubicin and unlabeled liposomes, with no significant effect on mouse body weight^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 1900734-29-3
Molecular Weight 1161.36
Formula C₄₄H₈₀N₂₀O₁₃S₂
Sequence

Cys-Arg-Lys-Arg-Leu-Asp-Arg-Asn-Cys (Disulfide bridge: Cys1-Cys9)
Sequence Shortening

CRKRLDRNC (Disulfide bridge: Cys1-Cys9)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (1)

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J Control Release

Nanoprodrug targeting tumor-associated intracellular bacteria enhances colorectal cancer immunotherapy. [Abstract]

2025 Dec 6:390:114512. PMID: 41360332

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (262 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Chi L, et al. Enhanced delivery of liposomes to lung tumor through targeting interleukin-4 receptor on both tumor cells and tumor endothelial cells. J Control Release. 2015;209:327-336. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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