2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-4Rα Antibody (REGN1103)

Anti-Mouse IL-4Rα Antibody (REGN1103) 

Cat. No.: HY-P992033
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Anti-Mouse IL-4Rα Antibody (REGN1103) is a mouse homologous antibody targeting IL-4Rα, as well as an inhibitor of IL-4 signaling. Anti-Mouse IL-4Rα Antibody (REGN1103) can be used in studies related to alveolar rhabdomyosarcoma.

For research use only. We do not sell to patients.

Anti-Mouse IL-4Rα Antibody (REGN1103)

Anti-Mouse IL-4Rα Antibody (REGN1103) Chemical Structure

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Anti-Mouse IL-4Rα Antibody (REGN1103) Related Antibodies

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Description

Anti-Mouse IL-4Rα Antibody (REGN1103) is a mouse homologous antibody targeting IL-4Rα, as well as an inhibitor of IL-4 signaling. Anti-Mouse IL-4Rα Antibody (REGN1103) can be used in studies related to alveolar rhabdomyosarcoma[1].

Isotype

Mouse IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Mouse
In Vivo

Anti-Mouse IL-4Rα Antibody (REGN1103) (25 mg/kg) treatment in SHO mice bearing orthotopic murine aRMS U48484 allografts results in no significant reduction in tumor volume or pulmonary metastatic burden, but is associated with shorter survival relative to isotype control[1].
Anti-Mouse IL-4Rα Antibody (REGN1103) (25 mg/kg) plus macrophage-depleting anti-CD115 antibody (25 mg/kg; i.p.; twice weekly) treatment in SHO mice bearing orthotopic murine aRMS U48484 allografts results in no significant differences in survival, tumor volume, or pulmonary metastatic burden relative to anti-CD115 monotreatment[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SHO mice (8-week-old female; B- and T-cell deficient)[1]
Dosage: 25 mg/kg (REGN1103); 25 mg/kg (anti-CD115)
Administration: i.p. (anti-CD115; twice weekly)
Result: Showed no significant difference in survival compared to anti-CD115 monotherapy (p=0.96).
Exhibited no significant difference in tumor volume compared to anti-CD115 monotherapy .
Showed no significant difference in pulmonary metastatic burden via rt-PCR analysis of Pax3:Foxo1 transcript levels, with a non-significant trend toward more lung metastases.
Gene ID

16190  [NCBI]

Accession

P16382
Target

CD124
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

[Anti-Mouse IL-4Rα Antibody (REGN1103)]
Formulation

Please refer to the lot-specific COA for specific buffer information.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse IL-4Rα Antibody (REGN1103) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-4Rα Antibody (REGN1103)Interleukin RelatedILmacrophageType II receptor complexesU48484IL-4 signalingIL-4RαType I receptor complexesSHO micemurine alveolar rhabdomyosarcomapulmonary metastatic burdenanti-CD115 antibodyInhibitorinhibitorinhibit

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