Il4ra - interleukin 4 receptor, alpha Gene

Also Known as Il4r; CD124

Species: Mus musculus

Gene Type: protein coding
Gene ID: 16190

Summary

Predicted to enable cytokine receptor activity. Involved in positive regulation of chemokine production; positive regulation of cold-induced thermogenesis; and positive regulation of macrophage activation. Acts upstream of or within several processes, including defense response to protozoan; negative regulation of T-helper 1 cell differentiation; and positive regulation of immune effector process. Predicted to be located in several cellular components, including centriolar satellite; extracellular space; and nucleoplasm. Predicted to be part of receptor complex. Is expressed in several structures, including adrenal medulla; early conceptus; hemolymphoid system; medulla oblongata basal plate mantle layer; and reproductive system. Used to study Asthma. Human ortholog(s) of this gene implicated in several diseases, including acne; allergic conjunctivitis; Autoimmune Disease (multiple); human immunodeficiency virus infectious disease; and renal Tuberculosis. Orthologous to human IL4R (interleukin 4 receptor). [provided by Alliance of Genome Resources, Apr 2022]

Il4ra Products (2)

mRNA Protein Name
NM_001008700.4 NP_001008700.1 interleukin-4 receptor subunit alpha isoform 1 precursor
NM_001363983.1 NP_001350912.1 interleukin-4 receptor subunit alpha isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
12242343 MGI
Biological Process GO Annotation Evidence Références Source
acts upstream of T-helper 1 cell differentiation IGI
IGI: Inferred from genetic interaction
16424184 MGI
acts upstream of T-helper 2 cell differentiation IGI
IGI: Inferred from genetic interaction
16424184 MGI
acts upstream of or within defense response to protozoan IMP
IMP: Inferred from mutant phenotype
7927664 MGI
acts upstream of or within immunoglobulin mediated immune response IMP
IMP: Inferred from mutant phenotype
15944273 MGI
acts upstream of or within negative regulation of T-helper 1 cell differentiation IGI
IGI: Inferred from genetic interaction
16424184 MGI
acts upstream of or within positive regulation of T-helper 2 cell differentiation IGI
IGI: Inferred from genetic interaction
16424184 MGI
involved in positive regulation of chemokine production IMP
IMP: Inferred from mutant phenotype
19841166 MGI
involved in positive regulation of cold-induced thermogenesis IMP
IMP: Inferred from mutant phenotype
24906148 MGI
acts upstream of or within positive regulation of immunoglobulin production IMP
IMP: Inferred from mutant phenotype
15944273 MGI
involved in positive regulation of macrophage activation IMP
IMP: Inferred from mutant phenotype
19841166 MGI
acts upstream of or within positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
15944273 MGI
acts upstream of or within positive regulation of myoblast fusion IMP
IMP: Inferred from mutant phenotype
12757709 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

interleukin-4 receptor subunit alpha

  • IL-4 receptor alpha chain

  • IL-4 receptor subunit alpha

  • IL-4R subunit alpha

  • IL-4R-alpha

Recombinant Il4ra Proteins

Cat. No. Nom du produit Accession Pureté
HY-P70305 IL-4R alpha/CD124 Protein, Mouse (HEK293, Fc) P16382-1 (I26-R233) ≥ 90%, as determined by reducing SDS-PAGE.
HY-P72541 IL-4R alpha/CD124 Protein, Mouse (HEK293, His) P16382-1 (I26-R233) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Clinical Phase
  • Pre-clinical Phase

Clinical Phase

Inhibitory Antibodies (1)
Cat. No. Nom du produit Effect
Pureté Phase
HY-P990983 Drotokibart Inhibitor 97.05% Phase 3

Pre-clinical Phase

Bioactive Molecules (2)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS06769 IL4R Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23551 Il4r Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
Inhibitory Antibodies (1)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-P991688 Gimvekibart Inhibitor 95.50% Unkown