Anti-Mouse IL-4 Antibody (11B11)
Based on 1 publication(s) in Google Scholar
Anti-Mouse IL-4 Antibody (11B11) is an anti-mouse IL-4 IgG1 monoclonal antibody. Anti-Mouse IL-4 Antibody (11B11) can inhibit Th2 cell differentiation by blocking the IL-4 signaling pathway. Anti-Mouse IL-4 Antibody (11B11) can significantly reduce fibrosis combined with anti-IL13 mAb. Anti-Mouse IL-4 Antibody (11B11) can be used for researches on cancer and inflammation conditions such as colorectal cancer and prostatitis.
For research use only. We do not sell to patients.
- Purity: 97.67%
- Molecular Weight:150 kDa
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) Anti-Mouse IL-4 Antibody (11B11)
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Biological Activity
Rat IgG1 kappa
Mouse
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IL-4 |
Anti-Mouse IL-4 Antibody (11B11) (10 μg/mL) helps to inhibit Th2 cell differentiation in the presence of TGF-β1 and IL-2 in CD4+ T cells from spleen of experimental autoimmune prostatitis (EAP) mice[2] .
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Anti-Mouse IL-4 Antibody (11B11) (500 μg/mouse, i.p., single dose, 1 hour before APTKA mCherry organoid injection) significantly reduces collagen deposition and Col1a1 expression by blocking the IL-4/IL-13 signaling pathway combined with anti-IL-13 mAb in C57BL/6 mice bearing APTKA mCherry organoid[3].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Type II collagen (50 μg) induced arthritis in female DBA/1J mice[1]
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Dosage:1 mg/kg
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Administration:Intraperitoneal injection (i.p.), once daily, for 10 days
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Result:Significantly increased incidence of arthritis (33% on day 18, 100% on day 26).
Significantly increased the severity of arthritis compared to the control group.
Significantly increased IgG2a antibody levels and decreased IgG1 antibody levels.
Enhanced delayed type hypersensitivity (DTH) of foot pads.
Significantly inhibited the secretion of IL-4 and increased the secretion of IFN-γ in lymph node cells from inguinal region of mice.
Significantly enhanced the proliferation response of lymph node cells to collagen II.
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Animal Model:C57BL/6 mice bearing APTKA mCherry organoid (8-12 weeks)[3]
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Dosage:500 μg/mouse, combined with anti-IL-13 mAb (200 μg)
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Administration:Intraperitoneal injection (i.p.), single dose, 1 hour before APTKA mCherry organoid injection
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Result:Reduced fibrosis and metastasis by blocking the IL-4/IL-13 signaling pathway.
Unconjugated
The product can be reconstituted/diluted with sterile PBS or saline.
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Product Image
ELISA, FACS, Functional assay, Research in vivo
Chemical Information
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Appearance Liquid
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Molecular Weight 150 kDa
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Color Colorless to light yellow
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SMILES
[Anti-Mouse IL-4 Antibody (11B11)]
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Publications (1)
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Journal Impact Factor
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Most Recent
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Acta Pharm Sin B
Macrophage P2Y6R activation aggravates psoriatic inflammation through IL-27-mediated Th1 responses. [Abstract]2024 Oct;14(10):4360-4377. PMID: 39525587
Purity & Documentation
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Data Sheet (263 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
References
[1]. Yoshino S. Effect of a monoclonal antibody against interleukin-4 on collagen-induced arthritis in mice. Br J Pharmacol. 1998 Jan;123(2):237-42. [Content Brief]
[2]. Guan Y, et al. IGF1R Promotes Th17/Treg Cell Development in Experimental Autoimmune Prostatitis. J Inflamm Res. 2025 Apr 30;18:5759-5775. [Content Brief]
[3]. Nater M, et al. Hepatic iNKT cells facilitate colorectal cancer metastasis by inducing a fibrotic niche in the liver. iScience. 2025 Apr 6;28(5):112364. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Anti-Mouse IL-4 Antibody (11B11) Related Classifications
HY-P990121 Related Classifications
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