KRO-105714
KRO-105714 is the antagonist for sphingosine phosphocholine receptor (SPC Receptor) and sphingosine-1-phosphate receptor 1 (S1P1 Receptor) (IC50=79.2 nM). KRO-105714 inhibits SPC-induced proliferation of NIH3T3 (IC50=5.6 nM), inhibits SPC-induced cell migration (IC50=0.59 μM) and tube formation in HUVECs. KRO-105714 inhibits SPC-induced generation of IL-4 and IL-5, exhibits anti-inflammtory efficacy in mouse atopic dermatitis models.
For research use only. We do not sell to patients.
- CAS No.: 1137536-21-0
- Formula: C26H30N4O3S
- Molecular Weight:478.61
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
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- References
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Help & FAQs
Biological Activity
Chemical Information
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CAS No. 1137536-21-0
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Molecular Weight 478.61
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Formula C26H30N4O3S
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SMILES
O=C(C1=C(NC(C(C)(C)C)=O)N=C(N2CCN(CC2)C3=C(OC)C=CC=C3)S1)C4=CC=CC=C4
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
KRO-105714 Related Classifications
HY-169864 Related Classifications
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