JAK3-IN-14
Based on 1 Customer Validation
JAK3-IN-14 (compound 1) is a potent JAK3 inhibitor, with IC50 values of 38 and 600 nM for JAK3 and JAK2, respectively. JAK3-IN-14 shows inhibitory of IL-4 and IL-3 induced TF-1 cell proliferation, with IC50 values of 600 and 500 nM, respectively.
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- Purity: 99.10%
- CAS No.: 454234-24-3
- 화학식: C18H13N3O
- 분자량:287.32
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보관:
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
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Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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용액&용해도
- 순도&문서
- References
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Help & FAQs
Biological Activity
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JAK3 38 nM (IC50) |
JAK2 600 nM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| CTLL | IC50 |
0.76 μM
Compound: 9
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Inhibitory activity against IL-2 induced proliferation of mouse CTLL cells
Inhibitory activity against IL-2 induced proliferation of mouse CTLL cells
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[PMID: 12941344] |
| T-cell | IC50 |
0.25 μM
Compound: 9
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Inhibitory activity against IL-2 induced proliferation of human T-cells
Inhibitory activity against IL-2 induced proliferation of human T-cells
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[PMID: 12941344] |
| TF-1 | IC50 |
500 nM
Compound: 1
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Inhibition of IL3-induced proliferation of TF1 cells
Inhibition of IL3-induced proliferation of TF1 cells
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[PMID: 16934457] |
| TF-1 | IC50 |
600 nM
Compound: 1
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Inhibition of IL4-induced proliferation of TF1 cells
Inhibition of IL4-induced proliferation of TF1 cells
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[PMID: 16934457] |
Chemical Information
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CAS No. 454234-24-3
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Appearance Solid
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분자량 287.32
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화학식 C18H13N3O
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Color Yellow to orange
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SMILES
O=C1NC2=CC=C(C3=CN=CC=C3)C=C2/C1=C/C4=CC=CN4
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선적
Room temperature in continental US; may vary elsewhere.
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보관
4°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
용액&용해도
DMSO : 125 mg/mL (435.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
순도&문서
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Data Sheet (273 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.4804 mL | 17.4022 mL | 34.8044 mL | 87.0110 mL |
| 5 mM | 0.6961 mL | 3.4804 mL | 6.9609 mL | 17.4022 mL | |
| 10 mM | 0.3480 mL | 1.7402 mL | 3.4804 mL | 8.7011 mL | |
| 15 mM | 0.2320 mL | 1.1601 mL | 2.3203 mL | 5.8007 mL | |
| 20 mM | 0.1740 mL | 0.8701 mL | 1.7402 mL | 4.3505 mL | |
| 25 mM | 0.1392 mL | 0.6961 mL | 1.3922 mL | 3.4804 mL | |
| 30 mM | 0.1160 mL | 0.5801 mL | 1.1601 mL | 2.9004 mL | |
| 40 mM | 0.0870 mL | 0.4351 mL | 0.8701 mL | 2.1753 mL | |
| 50 mM | 0.0696 mL | 0.3480 mL | 0.6961 mL | 1.7402 mL | |
| 60 mM | 0.0580 mL | 0.2900 mL | 0.5801 mL | 1.4502 mL | |
| 80 mM | 0.0435 mL | 0.2175 mL | 0.4351 mL | 1.0876 mL | |
| 100 mM | 0.0348 mL | 0.1740 mL | 0.3480 mL | 0.8701 mL |
JAK3-IN-14 Related Classifications
HY-155951 Related Classifications
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