Mapping the kinase domain of Janus Kinase 3

  • Bioorg Med Chem Lett. 2003 Sep 15;13(18):3105-10. doi: 10.1016/s0960-894x(03)00657-7.
Christopher Adams  1 ,  David J Aldous ,  Shelley Amendola ,  Paul Bamborough ,  Colin Bright ,  Sarah Crowe ,  Paul Eastwood ,  Garry Fenton ,  Martyn Foster ,  Trevor K P Harrison ,  Sue King ,  Justine Lai ,  Christopher Lawrence ,  Jean-Philippe Letallec ,  Clive McCarthy ,  Neil Moorcroft ,  Kenneth Page ,  Sudha Rao ,  Jane Redford ,  Shazia Sadiq ,  Keith Smith ,  John E Souness ,  Sukanthini Thurairatnam ,  Mark Vine ,  Barry Wyman
Affiliations
  • 1. Aventis Pharmaceuticals, 1041 Route 202-206, PO Box 6800, Bridgewater, NJ 08807, USA.
PMID: 12941344 DOI: 10.1016/s0960-894x(03)00657-7
Abstract

The utilization and impact of parallel synthesis on lead exploration around initial hit oxindole (1) are described. The emergent SAR, analogue design and functional impact will also be detailed.