Antitrypanosomal agent 10

Cat. No.: HY-151942: Data Sheet Handling Instructions
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Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM.

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Antitrypanosomal agent 10 화학구조

사이즈		재고
MOQ		Minimum order quantity
50 mg		견적 받기
100 mg		견적 받기
250 mg		견적 받기
Other size		견적 받기

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This product is a controlled substance and not for sale in your territory.

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

Biological Activity
순도&문서
References
고객리뷰

제품 설명

Antitrypanosomal agent 10 is an antitrypanosomal agent that inhibits Trypanosoma cruzi with an IC₅₀ of 0.28 μM^[1].

IC₅₀ & Target

Trypanosoma

Cellular Effect

Cell Line	Type	Value	Description	References
HepG2	CC₅₀	2.4 μM Compound: 46	Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against human HepG2 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
L6	CC₅₀	50 μM Compound: 46	Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against rat L6 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
MRC5	CC₅₀	>64 μM Compound: 46	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
NIH3T3	CC₅₀	>40 μM Compound: 46	Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against mouse 3T3 cells assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]
Peritoneal macrophage	CC₅₀	4 μM Compound: 46	Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay Cytotoxicity against primary peritoneal mouse macrophages assessed as reduction in cell viability measured after 24 hrs by colorimetric assay	[PMID: 36459758]

In Vitro

Antitrypanosomal agent 10 (compound 46) has good selectivity over mammalian cells, acceptable mouse liver microsome (MLM) clearance and lipophilicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

분자량

413.28

화학식

C₁₇H₉F₆N₅O

SMILES

N#CC1=CC=C2N=C(N(C2=C1)CC(F)(F)F)NC(C3=CC=NC(C(F)(F)F)=C3)=O

선적

Room temperature in continental US; may vary elsewhere.

보관

Please store the product under the recommended conditions in the Certificate of Analysis.

순도&문서

Handling Instructions (2659 KB)

References

[1]. Celso de Oliveira Rezende Júnior, et al. Hit-to-lead optimization of a 2-aminobenzimidazole series as new candidates for chagas disease.Eur J Med Chem. 2022 Nov 15;246:114925. [Content Brief]