BI 01383298
Based on 1 publication(s) in Google Scholar
BI 01383298 is an irreversible, selective inhibitor of the Na+-coupled citrate transporter SLC13A5 (NaCT) that blocks citrate uptake. BI 01383298 can be used for the research of metabolic disorders.
For research use only. We do not sell to patients.
The BI 01383298 was designed by Boehringer Ingelheim and could be obtained free of charge through the Boehringer Ingelheim open innovation portal opnMe.com, associated with its negative control.
- Purity : 99.44%
- CAS No.: 2227549-00-8
- Formula: C19H19Cl2FN2O3S
- Molecular Weight:445.34
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Storage:
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
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Publications Citing Use of MedChemExpress (MCE) BI 01383298
More
Biological Activity
Description
IC50 & Target
[1]|
SLC13A5 |
Cellular Effect
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HepG2 | IC50 |
24 nM
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Inhibition of citrate uptake in recombinant HepG2 cells expressing endogenous SLC13A5.
Inhibition of citrate uptake in recombinant HepG2 cells expressing endogenous SLC13A5.
|
37428122 |
| HEK293 | IC50 |
56 nM
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Inhibition of citrate uptake in recombinant HEK293 cells expressing hSCL13A5.
Inhibition of citrate uptake in recombinant HEK293 cells expressing hSCL13A5.
|
37428122 |
In Vitro
BI-01383298 is a highly selective, irreversible SLC13A5 inhibitor with IC50 values of 24 nM in recombinant HepG2 cells and 56 nM in recombinant hSCL13A5 HEK293 cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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CAS No. 2227549-00-8
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Appearance Solid
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Molecular Weight 445.34
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Formula C19H19Cl2FN2O3S
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Color White to off-white
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SMILES
O=C(C1CCN(S(=O)(C2=CC(Cl)=CC(Cl)=C2)=O)CC1)NCC3=CC=C(F)C=C3
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
-20°C, protect from light
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)
Publications (1)
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Journal Impact Factor
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Most Recent
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Nat Commun
Human iPSC-based Modeling of Pulmonary Fibrosis Reveals p300/CBP Inhibition Suppresses Alveolar Transitional Cell State. [Abstract]2026 Feb 12;17(1):1214. PMID: 41680175
Solvent & Solubility
In Vitro:
DMSO : 37.5 mg/mL (84.21 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Purity & Documentation
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Data Sheet (270 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.2455 mL | 11.2274 mL | 22.4548 mL | 56.1369 mL |
| 5 mM | 0.4491 mL | 2.2455 mL | 4.4910 mL | 11.2274 mL | |
| 10 mM | 0.2245 mL | 1.1227 mL | 2.2455 mL | 5.6137 mL | |
| 15 mM | 0.1497 mL | 0.7485 mL | 1.4970 mL | 3.7425 mL | |
| 20 mM | 0.1123 mL | 0.5614 mL | 1.1227 mL | 2.8068 mL | |
| 25 mM | 0.0898 mL | 0.4491 mL | 0.8982 mL | 2.2455 mL | |
| 30 mM | 0.0748 mL | 0.3742 mL | 0.7485 mL | 1.8712 mL | |
| 40 mM | 0.0561 mL | 0.2807 mL | 0.5614 mL | 1.4034 mL | |
| 50 mM | 0.0449 mL | 0.2245 mL | 0.4491 mL | 1.1227 mL | |
| 60 mM | 0.0374 mL | 0.1871 mL | 0.3742 mL | 0.9356 mL | |
| 80 mM | 0.0281 mL | 0.1403 mL | 0.2807 mL | 0.7017 mL |
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