BLT-1 (Synonyms: Block lipid transport-1)

Name: BLT-1
Brand: MedChemExpress
SKU: HY-116767
Rating: 5.0 (11 reviews)

製品番号: HY-116767 純度: 99.93%: Data Sheet SDS COA 取扱説明書
FAQs
Technical Support

BLT-1, a thiosemicarbazone copper chelator, is a selective scavenger receptor B, type 1 (SR-BI) inhibitor. BLT-1 inhibits the transfer of lipids between high-density lipoproteins (HDL) and cells mediated by SR-BI. BLT-1 is a potent HCV entry inhibitor.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号 : 321673-30-7

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 121	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$110	在庫あり	Estimated Time of Arrival: December 31
10 mg	$200	在庫あり	Estimated Time of Arrival: December 31
25 mg	$356	在庫あり	Estimated Time of Arrival: December 31
50 mg	$550	在庫あり	Estimated Time of Arrival: December 31
100 mg	$720	在庫あり	Estimated Time of Arrival: December 31
250 mg	$1050	在庫あり	Estimated Time of Arrival: December 31
500 mg		お問い合わせ
1 g		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

カスタマーレビュー

Based on 11 publication(s) in Google Scholar

顧客検証

Cell Imaging/Staining

In Vivo Efficacy Study

IHC

Cell Proliferation/Viability Assay

: BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]; BLT-1 (100 nM). Confocal laser scanning microscopy and quantification also revealed an increased proportion of γH2AX foci in PDCs after 48 h treatment. Scale bar, 10 μm.

: BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]; Both TMZ treatment alone and BLT-1 (100 nM) + TMZ cotreatment effectively reduced the growth of PDOs after 72 h treatment. Confocal images β-catenin in organoid co-treated with TMZ and BLT-1 and quantification of the mean intensity. Scale bar, 50 μm.

: BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]; Effect of TMZ treatment alone and BLT-1 (50 mg/kg/day, oral gavage for 3 weeks) + TMZ in PDX. Tumor weight, Tumor growth curves, and Representative graphs of tumors.

: BLT-1 purchased from MedChemExpress. Usage Cited in: Mol Ther. 2025 Dec 3;33(12):6518-6536. [Abstract]; IHC staining of PDX showed that the higher expression of β-catenin, and BRCA1/2 induced by TMZ was reversed by BLT-1 (50 mg/kg/day, oral gavage for 3 weeks) + TMZ. Scale bar, 50 μm.

: BLT-1 purchased from MedChemExpress. Usage Cited in: Cancer Discov. 2023 Feb 6;13(2):454-473. [Abstract]; Inhibition of the SR-B1 using the selective chemical inhibitor BLT-1 (5 µM) results in a modestly enhance DC661 cytotoxicity.

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製品説明

体外実験

BLT-1 has IC₅₀s of 60 and 110 nM for cellular DiI-HDL and [³H]CE-HDL uptake in ldlA[mSR-BI] cells^[1].
BLT-1 has an IC₅₀ of 0.96 μM for the HCV entry in Huh 7.5.1 cells^[4].
BLT-1 (50 μM; 3 hours) does not induce general defects in clathrin-dependent and -independent intracellular membrane trafficking in HeLa, BSC-1 cells^[1].
BLT-1 can inhibit SR-BI-dependent selective uptake of [³H]CE from [³H]CE-HDL by mSR-BI-t1-containing liposomes in cells (IC₅₀=0.057 μM) and liposomes (IC₅₀=0.098 μM) ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

241.40

分子式

C₁₂H₂₃N₃S

CAS 番号

321673-30-7

Appearance

Solid

Color

White to light yellow

SMILES

CCCCCCC1CCC/C1=N/NC(N)=S

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 41.67 mg/mL (172.62 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.1425 mL	20.7125 mL	41.4250 mL
5 mM	0.8285 mL	4.1425 mL	8.2850 mL
10 mM	0.4143 mL	2.0713 mL	4.1425 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: 2.08 mg/mL (8.62 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.08 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (8.62 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 99.93%

Select Batch:

データシート (276 KB) SDS (393 KB)

COA (249 KB) HNMR (245 KB) LCMS (97 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Nieland TJ, et al. Discovery of chemical inhibitors of the selective transfer of lipids mediated by the HDL receptorSR-BI. Proc Natl Acad Sci U S A. 2002 Nov 26;99(24):15422-7. [Content Brief]

[2]. Nieland TJ, et al. Identification of the molecular target of small molecule inhibitors of HDL receptor SR-BI activity. Biochemistry. 2008 Jan 8;47(1):460-72. [Content Brief]

[3]. Raldúa D, et al. BLT-1, a specific inhibitor of the HDL receptor SR-BI, induces a copper-dependent phenotype during zebrafish development. Toxicol Lett. 2007 Dec 10;175(1-3):1-7. Epub 2007 Aug 22. [Content Brief]

[4]. Hirofumi Ohashi, et al. Reply to Padmanabhan and Dixit: Hepatitis C virus entry inhibitors for optimally boosting direct-acting antiviral-based treatments. Proc Natl Acad Sci U S A. 2017 Jun 6;114(23):E4527-E4529. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.1425 mL	20.7125 mL	41.4250 mL	103.5626 mL
	5 mM	0.8285 mL	4.1425 mL	8.2850 mL	20.7125 mL
	10 mM	0.4143 mL	2.0713 mL	4.1425 mL	10.3563 mL
	15 mM	0.2762 mL	1.3808 mL	2.7617 mL	6.9042 mL
	20 mM	0.2071 mL	1.0356 mL	2.0713 mL	5.1781 mL
	25 mM	0.1657 mL	0.8285 mL	1.6570 mL	4.1425 mL
	30 mM	0.1381 mL	0.6904 mL	1.3808 mL	3.4521 mL
	40 mM	0.1036 mL	0.5178 mL	1.0356 mL	2.5891 mL
	50 mM	0.0829 mL	0.4143 mL	0.8285 mL	2.0713 mL
	60 mM	0.0690 mL	0.3452 mL	0.6904 mL	1.7260 mL
	80 mM	0.0518 mL	0.2589 mL	0.5178 mL	1.2945 mL
	100 mM	0.0414 mL	0.2071 mL	0.4143 mL	1.0356 mL

BLT-1 Related Classifications

Metabolic Disease Inflammation/Immunology

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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BLT-1 (Synonyms: Block lipid transport-1)

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BLT-1 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

BLT-1 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

BLT-1 Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

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最近チェックした製品:

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