2. PROTAC Protein Tyrosine Kinase/RTK NF-κB
  3. PROTACs Btk NF-κB
  4. Catadegbrutinib

Catadegbrutinib  (Synonyms: BGB-16673; BTK-IN-29)

製品番号: HY-160141 純度: 99.18%
COA 取扱説明書 Technical Support

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC50=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma.
(Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

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Catadegbrutinib

Catadegbrutinib 構造式

CAS 番号 : 2736508-60-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 356 在庫あり
Solution
10 mM * 1 mL in DMSO USD 356 在庫あり
Solid
1 mg $80 在庫あり
5 mg $190 在庫あり
10 mg $305 在庫あり
25 mg $488 在庫あり
50 mg $690 在庫あり
100 mg $970 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

* アイテムを追加する前、数量をご選択ください

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Catadegbrutinib 関連抗体

Top Publications Citing Use of Products

PROTACs アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

NF-κB アイソフォーム固有の製品をすべて表示:

すべてのアイソフォームを表示
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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製品説明

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC50=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma[1][2][3]. (Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

体内実験

Catadegbrutinib (6-20 mg/kg; p.o.) inhibits tumor growth in the REC‑1 lymphoma mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCG mice treated REC-1 cancer cells[2]
Dosage: 6 mg/kg; 20 mg/kg
Administration: p.o.
Result: Exhibited dose-dependent tumor growth inhibition.
Caused greater inhibition of cell-cycle-related genes than BTK inhibitors and more effectively inhibited NFκB targets than BTK inhibitors.
分子量

851.01

分子式

C47H54N12O4
CAS 番号
Appearance

Solid

Color

Light yellow to green yellow

SMILES

CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
溶剤 & 溶解度
体外: 

DMSO : 125 mg/mL (146.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1751 mL 5.8754 mL 11.7507 mL
5 mM 0.2350 mL 1.1751 mL 2.3501 mL
10 mM 0.1175 mL 0.5875 mL 1.1751 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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純度とドキュメンテーション

純度: 99.18%

COA (248 KB) HNMR (333 KB) RP-HPLC (253 KB) MS (68 KB)

取扱説明書 (2659 KB)
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1751 mL 5.8754 mL 11.7507 mL 29.3769 mL
5 mM 0.2350 mL 1.1751 mL 2.3501 mL 5.8754 mL
10 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9377 mL
15 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9585 mL
20 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
25 mM 0.0470 mL 0.2350 mL 0.4700 mL 1.1751 mL
30 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9792 mL
40 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
50 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5875 mL
60 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.4896 mL
80 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL
100 mM 0.0118 mL 0.0588 mL 0.1175 mL 0.2938 mL
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Catadegbrutinib Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catadegbrutinib2736508-60-2BGB-16673 BTK-IN-29BGB16673BGB 16673PROTACsBtkNF-κBBruton tyrosine kinaseNuclear factor-κBNuclear factor-kappaBperipheral bloodBTKNFκB targetsBCR signalingpolyubiquitinationmantle cell lymphomaWaldenstr?m macroglobulinemiaindolent non-Hodgkin lymphomaBcl-2 family memberstumor tissueInhibitorinhibitorinhibit

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