2. PROTAC Protein Tyrosine Kinase/RTK NF-κB
  3. PROTACs Btk NF-κB
  4. Catadegbrutinib

Catadegbrutinib  (Synonyms: BGB-16673; BTK-IN-29)

Cat. No.: HY-160141 Pureza: 99.18%
COA
SDS
Instrucciones de manejo Technical Support

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC50=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma.
(Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

Para uso exclusivo en investigación. No vendemos a pacientes.

Catadegbrutinib

Catadegbrutinib Estructura química

No. CAS : 2736508-60-2

Tamaño Precio Stock Cantidad
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 En stock
Solution
10 mM * 1 mL in DMSO En stock
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Catadegbrutinib Related Antibodies

Top Publications Citing Use of Products

Ver todos los productos específicos de isoformas PROTACs:

Ver todas las isoformas
von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

Ver todos los productos específicos de isoformas NF-κB:

Ver todas las isoformas
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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Descripciòn

BGB-16673 (BGB-16673) is an orally active, selective BTK PROTAC degrader (IC50=0.69 nM). BGB-16673 ligates BTK to E3 ubiquitin ligase, causing BTK to undergo polyubiquitination, which is then recognized and degraded by the proteasome, thereby exerting efficient BTK degradation activity. BGB-16673 can be used in the research of B-cell malignancies such as chronic lymphocytic leukemia, small lymphocytic lymphoma, and mantle cell lymphoma[1][2][3]. (Pink: Btk ligand (HY-175788); Blue: Cereblon ligand (HY-W245311); Black: linker).

In Vivo

Catadegbrutinib (6-20 mg/kg; p.o.) inhibits tumor growth in the REC‑1 lymphoma mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NCG mice treated REC-1 cancer cells[2]
Dosage: 6 mg/kg; 20 mg/kg
Administration: p.o.
Result: Exhibited dose-dependent tumor growth inhibition.
Caused greater inhibition of cell-cycle-related genes than BTK inhibitors and more effectively inhibited NFκB targets than BTK inhibitors.
Peso molecular

851.01

Fòrmula

C47H54N12O4
No. CAS
Appearance

Solid

Color

Light yellow to green yellow

SMILES

CC1=C([C@@H](C)NC(C2=NC(C(C)(C)C)=NO2)=O)C=CC(C3=C4C(NC(C5=CN=C(N6CCN(CC6)CC7CCN(C8=CC=C(N9C(NC(CC9)=O)=O)C=C8)CC7)C=C5)=C4)=NC=N3)=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad
In Vitro: 

DMSO : 125 mg/mL (146.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1751 mL 5.8754 mL 11.7507 mL
5 mM 0.2350 mL 1.1751 mL 2.3501 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Pureza y Documentación

Purity: 99.18%

SDS (252 KB)

COA (248 KB) HNMR (333 KB) RP-HPLC (253 KB) MS (68 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1751 mL 5.8754 mL 11.7507 mL 29.3769 mL
5 mM 0.2350 mL 1.1751 mL 2.3501 mL 5.8754 mL
10 mM 0.1175 mL 0.5875 mL 1.1751 mL 2.9377 mL
15 mM 0.0783 mL 0.3917 mL 0.7834 mL 1.9585 mL
20 mM 0.0588 mL 0.2938 mL 0.5875 mL 1.4688 mL
25 mM 0.0470 mL 0.2350 mL 0.4700 mL 1.1751 mL
30 mM 0.0392 mL 0.1958 mL 0.3917 mL 0.9792 mL
40 mM 0.0294 mL 0.1469 mL 0.2938 mL 0.7344 mL
50 mM 0.0235 mL 0.1175 mL 0.2350 mL 0.5875 mL
60 mM 0.0196 mL 0.0979 mL 0.1958 mL 0.4896 mL
80 mM 0.0147 mL 0.0734 mL 0.1469 mL 0.3672 mL
100 mM 0.0118 mL 0.0588 mL 0.1175 mL 0.2938 mL
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Catadegbrutinib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Catadegbrutinib2736508-60-2BGB-16673 BTK-IN-29BGB16673BGB 16673PROTACsBtkNF-κBBruton tyrosine kinaseNuclear factor-κBNuclear factor-kappaBperipheral bloodBTKNFκB targetsBCR signalingpolyubiquitinationmantle cell lymphomaWaldenstr?m macroglobulinemiaindolent non-Hodgkin lymphomaBcl-2 family memberstumor tissueInhibitorinhibitorinhibit

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Nombre del producto:
Catadegbrutinib
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