2. Others Immunology/Inflammation Neuronal Signaling NF-κB Apoptosis Metabolic Enzyme/Protease
  3. Reactive Oxygen Species (ROS) Environmental Pollutants Cholinesterase (ChE) Apoptosis Insecticide
  4. Carbaryl

カルバリル  (Synonyms: Carbaryl)

製品番号: HY-B1315 純度: 99.94%
COA 取扱説明書 Technical Support

Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide.

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Carbaryl

カルバリル 構造式

CAS 番号 : 63-25-2

容量 価格（税別） 在庫状況 数量
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 27 在庫あり
Solution
10 mM * 1 mL in DMSO USD 27 在庫あり
Solid
25 mg $25 在庫あり
50 mg $35 在庫あり
100 mg $50 在庫あり
200 mg   お問い合わせ  
500 mg   お問い合わせ  

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Other Forms of Carbaryl:

カルバリル 関連抗体

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Cholinesterase (ChE) アイソフォーム固有の製品をすべて表示:

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製品説明

Carbaryl is the inhibitor for acetylcholinesterase that inhibits the degradation of acetylcholine in the synaptic cleft, leads to the accumulation of acetylcholine and causes neurotoxicity. Carbaryl can be used as an insecticide[1][2].

体外実験

Carbaryl (1-8 ppm, 48 h) stimulates cell division and increases the cell number by 9.44% and 3.78% at 1 ppm and 2 ppm, inhibites cell growth and decreases the cell number by 11.32% and 33.96% at 4 ppm and 8 ppm, modulates the phospholipid content[2].
Carbaryl (20-40 μg/mL, 24 h) causes developmental delays, cardiac, neurodevelopmental and morphological defects, leads to cell death in cardiac region and nervous system in zebrafish embryos[3].
Carbaryl (10 μM, 8-12 h) increases the ROS level and induces oxidative stress in cell Neuro 2A, impairs mitochondrial functions, and induces apoptosis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

カルバリル 関連抗体

Apoptosis Analysis[4]

Cell Line: Neuro 2A
Concentration: 10 μM
Incubation Time: 8 h
Result: Induced apoptosis.

Real Time qPCR[4]

Cell Line: Neuro 2A
Concentration: 10 μM
Incubation Time: 8 h
Result: Upregulated the gene expression of Bax and Caspase-3, downregulated the gene expression of Bcl-2.
体内実験

Carbaryl (10-30 mg/kg, ip, 5 times a week for 28 days) inhibits the production of Th1 cytokines (such as IFN-γ), promotes the production of Th2 cytokines (such as IL-4 and IL-10), thereby changing the Th1/Th2 balance and exhibiting immunotoxicity in rats models[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rats models[5]
Dosage: 10-30 mg/kg
Administration: ip, 5 times a week for 28 days
Result: Reduced the weight of the spleen and thymus, inhibited the proliferation of spleen lymphocytes and the production of IL-2, increased the levels of IL-4 and IL-10 in serum, reduced the level of IFN-γ in serum and the levels of IL-1β and TNF-α produced by peritoneal macrophages.
分子量

201.22

分子式

C12H11NO2
CAS 番号
Appearance

Solid

Color

Off-white to pink

SMILES

O=C(OC1=C2C=CC=CC2=CC=C1)NC
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
溶剤 & 溶解度
体外: 

DMSO : 100 mg/mL (496.97 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9697 mL 24.8484 mL 49.6968 mL
5 mM 0.9939 mL 4.9697 mL 9.9394 mL
10 mM 0.4970 mL 2.4848 mL 4.9697 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始）

C1

×
体積 （開始）

V1

=
濃度 （終了）

C2

×
体積 （終了）

V2

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (12.42 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
純度とドキュメンテーション
参考文献

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.9697 mL 24.8484 mL 49.6968 mL 124.2421 mL
5 mM 0.9939 mL 4.9697 mL 9.9394 mL 24.8484 mL
10 mM 0.4970 mL 2.4848 mL 4.9697 mL 12.4242 mL
15 mM 0.3313 mL 1.6566 mL 3.3131 mL 8.2828 mL
20 mM 0.2485 mL 1.2424 mL 2.4848 mL 6.2121 mL
25 mM 0.1988 mL 0.9939 mL 1.9879 mL 4.9697 mL
30 mM 0.1657 mL 0.8283 mL 1.6566 mL 4.1414 mL
40 mM 0.1242 mL 0.6212 mL 1.2424 mL 3.1061 mL
50 mM 0.0994 mL 0.4970 mL 0.9939 mL 2.4848 mL
60 mM 0.0828 mL 0.4141 mL 0.8283 mL 2.0707 mL
80 mM 0.0621 mL 0.3106 mL 0.6212 mL 1.5530 mL
100 mM 0.0497 mL 0.2485 mL 0.4970 mL 1.2424 mL
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Carbaryl Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量   濃度   体積   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

一般には略語で表示されます：C1V1 = C2V2

濃度 （開始） × 体積 （開始） = 濃度 （終了） × 体積 （終了）
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Carbaryl63-25-2Reactive Oxygen Species (ROS)Environmental PollutantsCholinesterase (ChE)ApoptosisInsecticideEnvironmental ContaminantsNeuro 2AzebrafishinsecticideInhibitorinhibitorinhibit

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