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Carbazochrome 

Cat. No.: HY-B1587 Purity: 99.19%
Handling Instructions

Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent.

For research use only. We do not sell to patients.

Carbazochrome Chemical Structure

Carbazochrome Chemical Structure

CAS No. : 69-81-8

Size Price Stock Quantity
10 mM * 1  mL in Water USD 55 In-stock
Estimated Time of Arrival: December 31
250 mg USD 50 In-stock
Estimated Time of Arrival: December 31
500 mg   Get quote  
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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

Carbazochrome is a capillary stabiliser and used for the research of haemorrhage. Carbazochrome is an antihemorrhagic agent[1].

In Vitro

Carbazochrome (0.1-10 µM) inhibits the Bradykinin induced and thrombin-induced formation of [3H]IP3 in a concentration-dependent manner[1]. Carbazochrome (0.1-1 µM), when included from 30 min before stimulation, significantly suppressed the enhancement of permeability induced by vasoactive substances[1].

In Vivo

Carbazochrome inhibits the severe pulmonary dysfunction induced by the intravenous injection of radiographic contrast media. Carbazochrome (1-10 mg/kg, i.v.) attenuates pulmonary dysfunction induced by a radiographic contrast medium in rats[2].

Animal Model: Male Sprague-Dawley rats weighing 180-230 g[2]
Dosage: 10 mg/kg
Administration: I.v.; injected 30, 60, or 90 min before Ioxaglate injection (4 g I/kg, i.v.).
Result: Attenuated the Ioxaglate-increased vascular permeability at the dose of 1, 5 and 10 mg/kg in a dose-dependent manner, achieving statistical significance at 5 and 10 mg/kg.
Molecular Weight

236.23

Formula

C₁₀H₁₂N₄O₃

CAS No.

69-81-8

SMILES

O=C1/C(C=C2C(O)CN(C)C2=C1)=N\NC(N)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 5 mg/mL (21.17 mM; ultrasonic and adjust pH to 12 with NaOH)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.2332 mL 21.1658 mL 42.3316 mL
5 mM 0.8466 mL 4.2332 mL 8.4663 mL
10 mM 0.4233 mL 2.1166 mL 4.2332 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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Keywords:

CarbazochromeOtherscapillarystabiliserhaemorrhageantihemorrhagicInhibitorinhibitorinhibit

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Carbazochrome
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