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Casein kinase1δ-IN-4 (compound 567) is a potent casein kinase1δ inhibitor. Casein kinase1δ-IN-4 has the potential for the research of Alzheimer's disease [1].
Casein kinase1δ-IN-7 (compound 497) is a Casein kinase1δ inhibitor. Casein kinase1δ-IN-7 can be used in the study of neurodegenerative disorders such as Alzheimer's disease [1].
Casein kinase1δ-IN-8 (compound 494) is an inhibitor of Casein kinase1δ, Casein kinase1δ-IN-8 can be used in the treatment of neurodegenerative disorders such as Alzheimer's disease[1].
Casein kinase1δ-IN-1 (compound 822) is an inhibitor of casein kinase1 delta(CK1δ), exhibits inhibition of greater than 5%. Casein kinase1δ-IN-1 can be used for neurodegenerative disorders such as Alzheimer's disease research [1].
Casein kinase1δ-IN-9 (compound 737) is a potent casein kinase1δ (CK1δ/CK15) inhibitor. Casein kinase1δ-IN-9 can be used for the research of neurodegenerative disorders such as Alzheimer's disease [1].
Casein kinase1δ-IN-5 is a potent and selective protein kinaseCK-1δ inhibitor with an IC50 of 47 nM. Casein kinase1δ-IN-5 shows neuroprotective and anti-inflammatory properties both in vitro. Casein kinase1δ-IN-5 has the potential for neurodegenerative diseases research.
Casein kinase1δ-IN-6 is a potent and selective protein kinaseCK-1δ inhibitor with an IC50 of 23 nM. Casein kinase1δ-IN-6 shows neuroprotective and anti-inflammatory properties both in vitro and in vivo. Casein kinase1δ-IN-6 is a promising drug candidate and can be used for neurodegenerative diseases research.
Casein kinase1δ-IN-14 (compound 481) is a casein kinase inhibitor that can be used to study neurodegenerative diseases such as Alzheimer's disease [1].
PF-4800567 is a potent and selective inhibitor of casein kinase1ϵ (CK1ϵ), with an IC50 of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM).
Casein Kinase inhibitor A51 is a potent and orally active casein kinase1α (CK1α) inhibitor. Casein Kinase inhibitor A51 induces leukemia cell apoptosis, and has potent anti-leukemic activities [1].
CK1-IN-1 is a casein kinase1(CK1) inhibitor extracted from patent WO2015119579A1, compound 1c, has IC50s of 15 nM, 16 nM, 73 nM for CK1δ, and CK1ε, p38σ MAPK, respectively [1].
FPFT-2216, a “molecular glue” compound, degrades phosphodiesterase 6D (PDE6D), zinc finger transcription factors Ikaros (IKZF1), Aiolos (IKZF3), and casein kinase1α (CK1α). FPFT-2216 can be used for the research of cancer and inflammatory disease [1] .
Epiblastin A is an ATP competitive casein kinase1(CK1) inhibitor with IC50s of 8.9, 0.5, and 4.7 µM for CK1α, CK1δ, and CK1 ɛ, respectively. Epiblastin A induces reprogramming of epiblast stem cells into embryonic stem cells by inhibition of CK1[1].
Casein Kinase inhibitor A86 is a potent and orally active casein kinase1α (CK1α) inhibitor. Casein Kinase inhibitor A86 also inhibits of CDK7 (TFIIH) and CDK9 (P-TEFb). Casein Kinase inhibitor A861 induces leukemia cell apoptosis, and has potent anti-leukemic activities [1].
TMX-4116 is a casein kinase1α (CK1α) degrader. TMX-4116 shows the degradation preference for CK1α with DC50s less than 200 nM in MOLT4, Jurkat, and MM.1S cells. TMX-4116 can be used for the research of multiple myeloma [1].
PF-4800567 hydrochloride is a potent and selective inhibitor of?casein kinase?1? (CK1?), with an?IC50?of 32 nM, which is greater than 20-fold selectivity over CK1δ (IC50, 711 nM). PF-4800567 hydrochloride is useful in probing unique roles between these two kinases in multiple signaling pathways [1].
(R)-DRF053 dihydrochloride is a potent casein kinases1(CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model [1].
Umbralisib (TGR-1202) is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib can be used for haematological malignancies reseach [1] .
Umbralisib (TGR-1202) hydrochloride is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib hydrochloride exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib hydrochloride can be used for haematological malignancies reseach [1] .
Umbralisib (TGR-1202) tosylate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib tosylate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib tosylate can be used for haematological malignancies reseach [1] .
Umbralisib (TGR-1202) sulfate is an orally active, potent and selective dual PI3Kδ and casein kinase-1-ε (CK1ε) inhibitor, with EC50 of 22.2 nM and 6.0 μM, respectively. Umbralisib sulfate exhibits unique immunomodulatory effects on chronic lymphocytic leukemia (CLL) T cells. Umbralisib sulfate can be used for haematological malignancies reseach [1] .
AMG-548, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG 548 is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 inhibits Wnt signaling by directly inhibiting Casein kinase1 isoforms δ and ε .
AMG-548 dihydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 dihydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 dihydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase1 isoforms δ and ε .
AMG-548 hydrochloride, an orally active and selective p38α inhibitor (Ki=0.5 nM), shows slightly selective over p38β (Ki=36 nM) and >1000 fold selective against p38γ and p38δ. AMG-548 hydrochloride is also extremely potent in the inhibition of whole blood LPS stimulated TNFα (IC50=3 nM) [1]. AMG-548 hydrochloride inhibits Wnt signaling by directly inhibiting Casein kinase1 isoforms δ and ε .
CKI-7 is a potent and ATP-competitive casein kinase1(CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 is a selective Cdc7 kinase inhibitor. CKI-7 also inhibits SGK, ribosomal S6 kinase-1(S6K1) and mitogen- and stress-activated protein kinase-1(MSK1). CKI-7 has a much weaker effect on casein kinase II and other protein kinases[1] .
CKI-7 free base is a potent and ATP-competitive casein kinase1(CK1) inhibitor with an IC50 of 6 μM and a Ki of 8.5 μM. CKI-7 free base is a selective Cdc7 kinase inhibitor. CKI-7 free base also inhibits SGK, ribosomal S6 kinase-1(S6K1) and mitogen- and stress-activated protein kinase-1(MSK1). CKI-7 free base has a much weaker effect on casein kinase II and other protein kinases[1] .
CSNK1E protein is a casein kinase that preferentially phosphorylates acidic proteins such as casein. CSNK1E Protein, Human (His) is the recombinant human-derived CSNK1E protein, expressed by E. coli , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (His) is 416 a.a., with molecular weight of ~51.3 kDa.
CSNK1E, a member of the casein kinase family, is characterized by its preferential phosphorylation of acidic proteins, particularly caseins. The protein plays a pivotal role in Wnt signaling, as evidenced by its phosphorylation of DVL1 and DVL2, contributing to the intricate regulation of this pathway. Beyond its involvement in Wnt signaling, CSNK1E serves as a central component of the circadian clock, influencing the circadian period length by orchestrating the speed and rhythmicity of PER1 and PER2 phosphorylation. Acting in equilibrium with PP1, it governs the nuclear transport and degradation of PER1 and PER2, thereby intricately regulating the circadian rhythm. Additionally, CSNK1E demonstrates its regulatory influence by inhibiting cytokine-induced granulocytic differentiation, further emphasizing its multifaceted roles in cellular processes. CSNK1E Protein, Human (P. pastoris, His) is the recombinant human-derived CSNK1E protein, expressed by P. pastoris , with N-6*His labeled tag. The total length of CSNK1E Protein, Human (P. pastoris, His) is 416 a.a., with molecular weight of 49.3 kDa.
CSNK1A1; caseinkinase I isoform alpha; CKI-alpha; CK1
WB, IP
Human, Rat
Casein Kinase 1 alpha Antibody is a non-conjugated and Rabbit origined monoclonal antibody about 39 kDa, targeting to Casein Kinase 1 alpha. It can be used for WB,IP assays with tag free, in the background of Human, Rat.
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