1. Cell Cycle/DNA Damage
    Stem Cell/Wnt
  2. Casein Kinase
    Wnt
  3. SSTC3

SSTC3 

Cat. No.: HY-120675
Handling Instructions

SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors.

For research use only. We do not sell to patients.

SSTC3 Chemical Structure

SSTC3 Chemical Structure

CAS No. : 1242422-09-8

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Description

SSTC3 is a casein kinase 1α (CK1α) activator (Kd = 32 nM) that inhibits WNT signaling (EC50 = 30 nM). SSTC3 exhibits minimal gastrointestinal toxicity compared to other classes of WNT inhibitors[1].

In Vitro

SSTC3 (0-1μM, 5 days) decreases the viability of HCT116 cells in an on-target manner. This capacity is significantly reduced when the mutant CTNNB1 allele driving its carcinogenic properties is deleted[1].

Cell Viability Assay[1]

Cell Line: Colorectal cancer (CRC) cell lines.
Concentration: 0-1 μM.
Incubation Time: 5 days.
Result: Decreased the viability.

Western Blot Analysis[1]

Cell Line: SW403 cells.
Concentration: 100 nM.
Incubation Time: 15 min.
Result: Increased β-catenin phosphate levels.
In Vivo

SSTC3 can be maintained for 24 hours after treatment[1].
SSTC3 (25 mg/kg, ip once daily for 8-12 days) suppresses the growth of colorectal carcinoma in CD-1 mice[1].
SSTC3 (10 mg/kg, ip once daily for 1 month) inhibits the growth of Apc mutation-driven tumors[1].

Animal Model: Five-week-old Apcmin mice[1].
Dosage: 10 mg/kg.
Administration: IP for 1 month.
Result: Inhibited the growth of Apc mutation-driven tumors.
Animal Model: CD-1 mice.
Dosage: 25 mg/kg.
Administration: IP once daily for 8-12 days.
Result: Inhibited the growth of HCT116 xenografts.
Attenuated the growth of this metastatic CRC PDX and markedly reduced the cell density of residual cancer.
Reduced the expression of WNT biomarkers in this CRC PDX.
Molecular Weight

518.53

Formula

C₂₃H₁₇F₃N₄O₃S₂

CAS No.

1242422-09-8

SMILES

O=C(NC1=NC(C2=NC=CC=C2)=CS1)C3=CC=C(S(=O)(N(C)C4=CC=C(C(F)(F)F)C=C4)=O)C=C3

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Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

SSTC3SSTC 3SSTC-3Casein KinaseWntcolorectalcancerCTNNB1HCT116CRCSW403lowtoxicityInhibitorinhibitorinhibit

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