2. Cell Cycle/DNA Damage Stem Cell/Wnt
  3. CDK Casein Kinase
  4. (R)-DRF053 dihydrochloride

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model.

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(R)-DRF053 dihydrochloride Chemical Structure

(R)-DRF053 dihydrochloride Chemical Structure

CAS No. : 1241675-76-2

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(R)-DRF053 dihydrochloride Related Antibodies

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Description

(R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

IC50 & Target[1]

CK1

14 nM (IC50)

CDK1/cyclinB1

220 nM (IC50)

Cdk5/p25

80 nM (IC50)

Molecular Weight

490.43

Formula

C23H29Cl2N7O
CAS No.
SMILES

CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(R)-DRF053 dihydrochloride Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(R)-DRF0531241675-76-2CDKCasein KinaseCyclin dependent kinaseCDK1/cyclin BCDK5/p25CK1Inhibitorinhibitorinhibit

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