1241675-76-2
1241675-76-2
Chemical Structure
(R)-DRF053 dihydrochloride
- No. CAS: 1241675-76-2
- Formula:C23H29Cl2N7O
- Molecular Weight:490.43
IUPAC Name: (R)-2-((9-isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol dihydrochloride
InChIKey: BQPRBNGSDBTKAK-ZEECNFPPSA-N
SMILES: CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl
Biological Activity: (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].
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(R)-DRF053 dihydrochloride | 99.30% | (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model. | ||||||||||||||||||||
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