1241675-76-2

(R)-DRF053 dihydrochloride Chemical Structure
1241675-76-2

Chemical Structure

(R)-DRF053 dihydrochloride

  • CAS No.: 1241675-76-2
  • Formula:C23H29Cl2N7O
  • Molecular Weight:490.43

IUPAC Name: (R)-2-((9-isopropyl-6-((3-(pyridin-2-yl)phenyl)amino)-9H-purin-2-yl)amino)butan-1-ol dihydrochloride

InChIKey: BQPRBNGSDBTKAK-ZEECNFPPSA-N

SMILES: CC(C)N1C2=NC(N[C@@H](CO)CC)=NC(NC3=CC(C4=CC=CC=N4)=CC=C3)=C2N=C1.Cl.Cl

Biological Activity: (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model[1].

Cat. No. Product Name Purity Description Pricing
HY-103383 		(R)-DRF053 dihydrochloride 99.30% (R)-DRF053 dihydrochloride is a potent casein kinases 1 (CK1), CDK1/cyclin B and CDK5/p25 inhibitor with IC50s of 14 nM, 220 nM and 80 nM, respectively. (R)-DRF053 dihydrochloride prevents the CK1-dependent production of amyloid-beta in a cell model.
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