2. Metabolic Enzyme/Protease
  3. Cathepsin
  4. Cathepsin K inhibitor 3

Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies.

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Cathepsin K inhibitor 3

Cathepsin K inhibitor 3 Chemical Structure

CAS No. : 1694638-70-4

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Cathepsin K inhibitor 3 Related Antibodies

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Cathepsin B Cathepsin C Cathepsin D Cathepsin E Cathepsin K Cathepsin L Cathepsin S

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Description

Cathepsin K inhibitor 3 (compound 23) is a highly selective cathepsin K inhibitor with an IC50 value of 0.5 nM. Cathepsin K inhibitor 3 has a favorable pharmacokinetic profile and may be used in osteoarthritis (OA) disease studies[1].

IC50 & Target[1]

cathepsin K

0.5 nM (IC50)

In Vivo

Cathepsin K inhibitor 3 (compound 23) (p.o., 0.03-15 mg/kg, daily, 4 days) results in a significant and dose-dependent reduction in uCTX-I, with an 81% reduction in uCTX-1 levels at 0.3 mg/kg and a slightly more complete reduction at 15 mg/kg in dog[1].
The pharmacokinetic parameters of compound 23

Parameters Cl(mL/min/kg) T1/2(h) %F
Rat 13 1 33
Dog 3.1 4.1 38
Rhesus 18.5 2.3 55

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Masse moléculaire

562.65

Formule

C30H31FN4O4S
CAS No.
SMILES

O=S1(CCN(CC1)C2=CC=C(C3=C([C@@H]4CCCC[C@H]4C(NC5(CC5)C#N)=O)OC(C6=CC=C(C=C6)F)=N3)C=C2)=O
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
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Cathepsin K inhibitor 3 Related Classifications

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Keywords:

Cathepsin K inhibitor 31694638-70-4Cathepsin K inhibitor3Cathepsin K inhibitor-3CathepsinCathepsin KosteoarthritisInhibitorinhibitorinhibit

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