1. Membrane Transporter/Ion Channel
  2. Potassium Channel
  3. Cloperastine hydrochloride

Cloperastine hydrochloride 

Cat. No.: HY-B2133
Handling Instructions

Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM.

For research use only. We do not sell to patients.

Cloperastine hydrochloride Chemical Structure

Cloperastine hydrochloride Chemical Structure

CAS No. : 14984-68-0

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Description

Cloperastine hydrochloride inhibits the hERG K+ currents in a concentration-dependent manner with an IC50 value of 27 nM[1].

IC50 & Target

27 nM (K+ currents)[1]

In Vitro

Cloperastine inhibits the hERG K+ currents in a concentrationdependent manner with an IC50 value of 27 nM[1].
Among the antitussive agents, Cloperastine, which possesses antitussive and antiedemic activity, also relaxes the bronchial musculature. Cloperastine is a drug with a central antitussive effect, and is also endowed with an antihistaminic and papaverine-like activity similar to codeine but without its narcotic effects[2].

In Vivo

In the anesthetized guinea pigs, Cloperastine at a therapeutic dose of 1 mg/kg prolonged the QT interval and monophasic action potential (MAP) duration without affecting PR interval or QRS width[1].
Cloperastine hydrochloride shows relatively low acute toxicity when administered by the intraperitoneal route in rats and mice, and shows minor toxicity by the oral route when administered as Cloperastine fendizoate, the LD50 in rats and mice for the two administration routes exceeds 1000 and 2000 mg/kg, respectively[2].

Molecular Weight

366.32

Formula

C₂₀H₂₅Cl₂NO

CAS No.

14984-68-0

SMILES

ClC1=CC=C(C(C2=CC=CC=C2)OCCN3CCCCC3)C=C1.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

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Keywords:

CloperastinePotassium ChannelKcsAInhibitorinhibitorinhibit

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Cloperastine hydrochloride
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