CMP-Sialic acid (Synonyms: CMP-Neu5Ac)

Art. -Nr.: HY-112942: Data Sheet Handling Instructions
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CMP-Sialic acid (CMP-Neu5Ac) is an allosteric inhibitor of UDP-GlcNAc 2-epimerase. CMP-Sialic acid provides a substrate for Golgi sialyltransferases. CMP-Sialic acid is an important sugar nucleotide for biosynthesis of sialic acid and its conjugates.

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CMP-Sialic acid Chemische Struktur

CAS. Nr. : 3063-71-6

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Other In-stock Forms of CMP-Sialic acid:

CMP-Sialic acid sodium salt

Other Forms of CMP-Sialic acid:

CMP-Sialic acid sodium salt In-stock

4 Publications Citing Use of MCE CMP-Sialic acid

Spezialitätsempfehlungen

•Related Small Molecules:

•Related Proteins:

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen:

Alle Isoformen anzeigen

Human Endogenous Metabolite Microbial Metabolite

Biologische Aktivität
Reinheit & Dokumentation
Verweise
Kundenbewertung

Beschreibung

IC₅₀ & Target

Human Endogenous Metabolite

In Vitro

CMP-Sialic acid (22.5 μM, 45 min) can be used as a CMAH substrate to detect the formation of Neu5Gc in platelet lysates^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molekulargewicht

614.45

Formel

C₂₀H₃₁N₄O₁₆P

CAS. Nr.

3063-71-6

SMILES

O[C@@H]1[C@H](O[C@@H](N2C(N=C(N)C=C2)=O)[C@@H]1O)COP(O[C@@]3(O[C@@]([C@H](NC(C)=O)[C@@H](O)C3)([H])[C@H](O)[C@H](O)CO)C(O)=O)(O)=O

Structure Classification

Others

Initial Source

Versand

Room temperature in continental US; may vary elsewhere.

Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Münster AK, et al. Mammalian cytidine 5'-monophosphate N-acetylneuraminic acid synthetase: a nuclear protein with evolutionarily conserved structural motifs. Proc Natl Acad Sci U S A. 1998 Aug 4;95(16):9140-5. [Content Brief]

[2]. Jing Song, et al. Reassembled Biosynthetic Pathway for a Large-scale Synthesis of CMP-Neu5Ac. Mar Drugs. 2003 Dec; 1(4): 34-45.

[3]. Mercado CP, et al. A serotonin-induced N-glycan switch regulates platelet aggregation. Sci Rep. 2013 Sep 30;3:2795. [Content Brief]

CMP-Sialic acid Related Classifications

Metabolic Disease

Molaritätsrechner
Verdünnungsrechner

Die Formel zur Berechnung von Molaritäten

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Diese Gleichung wird häufig abgekürzt als: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CMP-Sialic acid3063-71-6CMP-Neu5AcEndogenous MetaboliteUDP-GlcNAc 2-epimerasesialicacidGolgisialyltransferasessugardonornucleotidesubstrateInhibitorinhibitorinhibit

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