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  4. Curvularin

Curvularin  (Synonyms: (S)-Curvularin)

製品番号: HY-N6770 純度: 99.99%
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Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM.

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Curvularin

Curvularin 構造式

CAS 番号 : 10140-70-2

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1 mg $238 在庫あり
5 mg $594 お問い合わせ
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Curvularin 関連抗体

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nNOS iNOS eNOS

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製品説明

Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2].

IC50 & Target

iNOS

 

Cellular Effect
Cell Line Type Value Description References
HepG2 IC50
34.2 μM
Compound: (S)-Curvularin
Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after
Binding affinity to (AGCCAGACA)9-MLP element (unknown origin) transiently transfected in human HepG2 cells assessed as inhibition of TGF-beta-induced Smad-dependent transcriptional activity preincubated for 1 hr before TGF-beta stimulation measured after
[PMID: 25537529]
HepG2 IC50
86.4 μM
Compound: (S)-Curvularin
Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay
Inhibition of TGF-beta-induced human CTGF promoter activity transiently transfected in human HepG2 cells after 16 hrs by luciferase reporter assay
[PMID: 25537529]
分子量

292.33

分子式

C16H20O5
CAS 番号
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[C@@H](C)CCCCC1)CC2=CC(O)=CC(O)=C2C1=O
Structure Classification
Initial Source

fungus Eupenicillium sp
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件
Powder -20°C 3 years
In solvent -80°C 6 months
  -20°C 1 month
純度とドキュメンテーション
参考文献
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Curvularin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Curvularin10140-70-2(S)-CurvularinNO SynthaseNitric oxide synthasesNOSInhibitorinhibitorinhibit

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Curvularin
製品番号:
HY-N6770
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