2. Metabolic Enzyme/Protease Protein Tyrosine Kinase/RTK
  3. HIF/HIF Prolyl-Hydroxylase VEGFR
  4. cyclo(CLLFVY)

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers.

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cyclo(CLLFVY)

cyclo(CLLFVY) Estructura química

No. CAS : 1446322-73-1

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cyclo(CLLFVY) Related Antibodies

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Descripciòn

cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].

Peso molecular

738.94

Fòrmula

C38H54N6O7S
No. CAS
Appearance

Solid

Color

White to off-white

Sequence

cyclo(Cys-Leu-Leu-Phe-Val-Tyr)
Sequence Shortening

cyclo(CLLFVY)
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (135.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3533 mL 6.7664 mL 13.5329 mL
5 mM 0.2707 mL 1.3533 mL 2.7066 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Pureza y Documentación

Purity: 99.37%

SDS (252 KB)

COA (259 KB) LCMS (88 KB)

Instrucciones de manejo (2659 KB)
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.3533 mL 6.7664 mL 13.5329 mL 33.8322 mL
5 mM 0.2707 mL 1.3533 mL 2.7066 mL 6.7664 mL
10 mM 0.1353 mL 0.6766 mL 1.3533 mL 3.3832 mL
15 mM 0.0902 mL 0.4511 mL 0.9022 mL 2.2555 mL
20 mM 0.0677 mL 0.3383 mL 0.6766 mL 1.6916 mL
25 mM 0.0541 mL 0.2707 mL 0.5413 mL 1.3533 mL
30 mM 0.0451 mL 0.2255 mL 0.4511 mL 1.1277 mL
40 mM 0.0338 mL 0.1692 mL 0.3383 mL 0.8458 mL
50 mM 0.0271 mL 0.1353 mL 0.2707 mL 0.6766 mL
60 mM 0.0226 mL 0.1128 mL 0.2255 mL 0.5639 mL
80 mM 0.0169 mL 0.0846 mL 0.1692 mL 0.4229 mL
100 mM 0.0135 mL 0.0677 mL 0.1353 mL 0.3383 mL
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cyclo(CLLFVY) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

cyclo(CLLFVY)1446322-73-1HIF/HIF Prolyl-HydroxylaseVEGFRHypoxia-inducible factorsHIFsHIF-PHVascular endothelial growth factor receptorU2OSMCF-7Inhibitorinhibitorinhibit

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Nombre del producto:
cyclo(CLLFVY)
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HY-P10426
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