1446322-73-1
Chemical Structure
cyclo(CLLFVY)
- CAS No.: 1446322-73-1
- Formula:C38H54N6O7S
- Molecular Weight:738.94
InChIKey: RQPVXDHMQMNAII-JNRWAQIZSA-N
SMILES: O=C(N[C@@H](CC(C)C)C(N[C@@H](CC(C)C)C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](C(C)C)C(N[C@H]2CC3=CC=C(C=C3)O)=O)=O)=O)=O)[C@H](CS)NC2=O
Biological Activity: cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers[1].
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cyclo(CLLFVY) | 97.98% | cyclo(CLLFVY) is an inhibitor for hypoxia inducible factor-1 (HIF-1), with IC50 of 19 μM (in U2OS) and 16 μM (in MCF-7). cyclo(CLLFVY) binds to the PAS-B domain of HIF-1α, inhibits HIF-1 dimerization and transcriptional activity. cyclo(CLLFVY) downregulates the expression of hypoxia response genes, such as VEGF and CAIX, exhibits antitumor against the HIF-1 associated cancers. | ||||||||||||||||||||
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