Cycloastragenol (Synonyms: Astramembrangenin; Cyclosieversigenin; シクロアストラゲノール)

Name: Cycloastragenol
Brand: MedChemExpress
SKU: HY-N1485
Rating: 5.0 (8 reviews)

製品番号: HY-N1485 純度: 98.0%: Data Sheet SDS COA 取扱説明書
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Cycloastragenol (Astramembrangenin), the active form of astragaloside IV, has anti-oxidant, anti-inflammatory, anti-aging, anti-apoptotic, and cardiovascular protective effects. Cycloastragenol is a potent telomerase activator and can lengthen telomeres. Cycloastragenol alleviates age-related bone loss and improves bone microstructure and biomechanical properties.

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CAS 番号 : 78574-94-4

容量	価格（税別）	在庫状況	数量

>無料サンプル (0.1 - 0.2 mg)		今すぐ申し込む
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 54	在庫あり	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 54	在庫あり	Estimated Time of Arrival: December 31
Solid
5 mg	$50	在庫あり	Estimated Time of Arrival: December 31
10 mg	$70	在庫あり	Estimated Time of Arrival: December 31
25 mg	$95	在庫あり	Estimated Time of Arrival: December 31
50 mg	$145	在庫あり	Estimated Time of Arrival: December 31
100 mg	$215	在庫あり	Estimated Time of Arrival: December 31
200 mg		お問い合わせ
500 mg		お問い合わせ

or バルクお問い合わせ

* アイテムを追加する前、数量をご選択ください

This product is a controlled substance and not for sale in your territory.

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Based on 8 publication(s) in Google Scholar

Other Forms of Cycloastragenol:

Cyclogalegenin 在庫あり
Cycloastragenol (Standard) お問い合わせ

顧客検証

In Vivo Efficacy Study

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Phytother Res. 2026 Apr;40(4):1626-1641.; Cycloastragenol (CAG; 20, 100, 500 μg/kg; Intrathecal injection) dose- dependently improved paw withdrawal threshold (PWT) in Bone cancer pain (BCP) rats.

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Phytother Res. 2026 Apr;40(4):1626-1641.; Dose–response relationship of Cycloastragenol (CAG; 125, 250, 375, 500 μg/kg) showed increased antinociceptive effects with higher doses.

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Phytother Res. 2026 Apr;40(4):1626-1641.; Cycloastragenol (CAG; 20, 100, 500 μg/kg; Intrathecal injection) significantly and dose-dependently reduced the Iba-1 expression, with thestrongest inhibition observed at 500 μg/kg in spinal dorsal horn of Bone cancer pain (BCP) rats.

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Phytother Res. 2026 Apr;40(4):1626-1641.; Cycloastragenol (CAG; 20, 100, 500 μg/kg; Intrathecal injection) significantly decreased in Iba-1 protein levels in Bone cancer pain (BCP) rats.

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Phytother Res. 2026 Apr;40(4):1626-1641.; Cycloastragenol (CAG; 20, 100, 500 μg/kg; Intrathecal injection) didnot significantly alter GFAP levels at any dose in spinal dorsal horn of Bone cancer pain (BCP) rats.

: Cycloastragenol purchased from MedChemExpress. Usage Cited in: Int J Mol Sci. 2023 Mar 31;24(7):6554.; Cycloastragenol (CAG; 50,100 μM; 48 h) decreases the expression of PAI-1 and p21 in HELF cells.

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製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	1.542 μM Compound: 8	Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human A549 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
DU-145	IC₅₀	7.258 μM Compound: 8	Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human DU145 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
HEK293	IC₅₀	127.7 μM Compound: 8	Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HEK293 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
HeLa	IC₅₀	2.198 μM Compound: 8	Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human HeLa cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]
MCF7	IC₅₀	1.778 μM Compound: 8	Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay Cytotoxicity against human MCF7 cells assessed as reduction in cell viability after 48 hrs by MTT assay	[PMID: 28482219]

体外実験

Cycloastragenol (0.03-3 μM; 24-72 hours) promotes viability, osteoblastic differentiation, and mineralization in MC3T3-E1 cells^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Cycloastragenol (5, 10, 20 mg/kg) is injected intraperitoneally at the onset of reperfusion, 12 h later and then twice daily for up to three days. Cycloastragenol dose-dependently reduces brain infarct volume, significantly ameliorated functional deficits, and prevents neuronal cell loss in middle cerebral artery occlusion (MCAO) mice. Cycloastragenol suppresses the mRNA expression of pro-inflammatory cytokines, including TNF-α and IL-1β, and inhibits the activation of microglia and astrocytes in the ischemic brain^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

臨床実験

分子量

490.72

分子式

C₃₀H₅₀O₅

CAS 番号

78574-94-4

Appearance

Solid

Color

White to off-white

SMILES

CC1(C)[C@@H](O)CC[C@]2(C3)[C@]43CC[C@]5(C)[C@@H]([C@](C)(O6)CC[C@H]6C(C)(O)C)[C@@H](O)C[C@](C)5[C@]4([H])C[C@H](O)[C@@]12[H]

Structure Classification

Initial Source

輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶剤 & 溶解度

体外:

DMSO : 66.67 mg/mL (135.86 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0378 mL	10.1891 mL	20.3782 mL
5 mM	0.4076 mL	2.0378 mL	4.0756 mL
10 mM	0.2038 mL	1.0189 mL	2.0378 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）

体積 _（開始）

濃度 _（終了）

体積 _（終了）

体内:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (5.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 2

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (4.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

純度とドキュメンテーション

純度: 98.0%

Select Batch:

データシート (280 KB) SDS (393 KB)

COA (258 KB) HNMR (302 KB) MS (68 KB)

取扱説明書 (2659 KB)

参考文献

[1]. Yu Y, et al. Cycloastragenol: An exciting novel candidate for age-associated diseases. Exp Ther Med. 2018;16(3):2175-2182. [Content Brief]

[2]. Li M, et al. Cycloastragenol upregulates SIRT1 expression, attenuates apoptosis and suppresses neuroinflammation after brain ischemia. Acta Pharmacol Sin. 2020;41(8):1025-1032. [Content Brief]

[3]. Yu Y, et al. Cycloastragenol prevents age-related bone loss: Evidence in d-galactose-treated and aged rats. Biomed Pharmacother. 2020;128:110304. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0378 mL	10.1891 mL	20.3782 mL	50.9455 mL
	5 mM	0.4076 mL	2.0378 mL	4.0756 mL	10.1891 mL
	10 mM	0.2038 mL	1.0189 mL	2.0378 mL	5.0946 mL
	15 mM	0.1359 mL	0.6793 mL	1.3585 mL	3.3964 mL
	20 mM	0.1019 mL	0.5095 mL	1.0189 mL	2.5473 mL
	25 mM	0.0815 mL	0.4076 mL	0.8151 mL	2.0378 mL
	30 mM	0.0679 mL	0.3396 mL	0.6793 mL	1.6982 mL
	40 mM	0.0509 mL	0.2547 mL	0.5095 mL	1.2736 mL
	50 mM	0.0408 mL	0.2038 mL	0.4076 mL	1.0189 mL
	60 mM	0.0340 mL	0.1698 mL	0.3396 mL	0.8491 mL
	80 mM	0.0255 mL	0.1274 mL	0.2547 mL	0.6368 mL
	100 mM	0.0204 mL	0.1019 mL	0.2038 mL	0.5095 mL

Cycloastragenol Related Classifications

Neurological Disease Inflammation/Immunology Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

質量		濃度		体積		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

一般には略語で表示されます：C₁V₁ = C₂V₂

濃度 _（開始）	×	体積 _（開始）	=	濃度 _（終了）	×	体積 _（終了）
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cycloastragenol78574-94-4Astramembrangenin CyclosieversigeninTelomerasebonelossmicrogliacerebralreperfusionneuroinflammationamelioratedInhibitorinhibitorinhibit

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Cycloastragenol (Synonyms: Astramembrangenin; Cyclosieversigenin; シクロアストラゲノール)

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Other Forms of Cycloastragenol:

Cycloastragenol 関連抗体

顧客検証

おすすめ

•関連スクリーニングライブラリ:

•関連小分子:

•関連タンパク質:

生物活性

純度とドキュメンテーション

参考文献

カスタマーレビュー

Cycloastragenol 関連抗体

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

Cycloastragenol Related Classifications

Molarity Calculator

Dilution Calculator

The molarity calculator equation

The dilution calculator equation

Keywords:

最近チェックした製品:

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