2. PROTAC Cell Cycle/DNA Damage Autophagy Apoptosis Immunology/Inflammation
  3. PROTACs FKBP
  4. dTAGV-1-NEG TFA

dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader.

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dTAGV-1-NEG TFA

dTAGV-1-NEG TFA Estructura química

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dTAGV-1-NEG TFA Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Descripciòn

dTAGV-1-NEG TFA is a diastereomer and as a heterobifunctional negative control of dTAGV-1. dTAGV-1-NEG TFA is an FKBP12F36V-selective degrader[1].

IC50 & Target

FKBP12

 

In Vitro

dTAGV-1-NEG TFA (1-10 μM; 24 h) not induces the degradation of FKBP12F36V-Nluc on 293FT FKBP12F36V-Nluc or FKBP12WT-Nluc cells[1].
dTAGV-1-NEG TFA (500 nM; 24 h) dose not induce the degradation of KRASG12V protein in PATU-8902 FKBP12F36V-KRASG12V and KRAS / cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

dTAGV-1-NEG TFA Related Antibodies

Western Blot Analysis[1]

Cell Line: PATU-8902 FKBP12F36V-KRASG12V, KRAS−/− cells
Concentration: 50, 500 nM
Incubation Time: 24 hours
Result: Not induced the degradation of KRASG12V protein.

Cell Viability Assay[1]

Cell Line: EWS502 FKBP12F36V-GFP cells
Concentration: 1 μM
Incubation Time: 0, 2, 4, 6, 8 days
Result: Showed relative growth of cells same as the control group, higher than dTAGV-1 treated group.
Peso molecular

1361.56

Fòrmula

C70H91F3N6O16S
SMILES

O=C([C@H]1N(C([C@H](C2=CC(OC)=C(OC)C(OC)=C2)CC)=O)CCCC1)O[C@@H](C3=CC=CC=C3OCC(NCCCCCCC(N[C@@H](C(C)(C)C)C(N4[C@@H](C(N[C@H](C5=CC=C(C6=C(C)N=CS6)C=C5)C)=O)C[C@H](O)C4)=O)=O)=O)CCC7=CC=C(OC)C(OC)=C7.OC(C(F)(F)F)=O
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Room temperature in continental US; may vary elsewhere.
Almacenamiento

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Referencias
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dTAGV-1-NEG TFA Related Classifications

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Keywords:

dTAGV-1-NEGPROTACsFKBPFK506-binding proteinvon Hippel-LindauVHLE3 ligaseheterobifunctional negative controldTAGV-1KRASG12VInhibitorinhibitorinhibit

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Nombre del producto:
dTAGV-1-NEG TFA
Cat. No.:
HY-145514B
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