2. Membrane Transporter/Ion Channel
  3. Potassium Channel
  4. Fenquizone

Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics.​ Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension.

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Fenquizone

Fenquizone Estructura química

No. CAS : 20287-37-0

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10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
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Descripciòn

Fenquizone (MG-13054) is an orally active diuretic. Fenquizone acts primarily on the diluting segment of the nephron cortex, similar to thiazide diuretics. Fenquizone demonstrates diuretic and natriuretic potency and duration of action comparable to thiazide diuretics but weaker than loop diuretics.​ Fenquizone reduces CH₂O without affecting TCH₂O, does not increase calcium/phosphate excretion, and has no loop or collecting duct effects. Fenquizone is used in the study of edema and hypertension[1].

In Vivo

Fenquizone (0.05-100 mg/kg, p.o., sinle dose) demonstrates a diuretic effect comparable to Hydrochlorothiazide (HY-B0252) and Quinethazone (HY-B1364), though it is less potent than Furosemide (HY-B0135) at 50 mg/kg in rats[1].
Fenquizone (50 mg/kg, p.o., sinle dose) does not cause significant changes in blood glucose, plasma uric acid, or urine uric acid concentrations whether administered acutely or chronically in mice[1].
Fenquizone (i.v., single dose) inhibits sodium reabsorption in the cortical dilution segment, without affecting the loop of Henle or the collecting duct[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Fast overnight model established in male Sprague-Dawley rats (180-245 g)[1]
Dosage: 0.5, 1, 5, 20, 50 and 100 mg/kg
Administration: Oral administration (p.o.), single dose
Result: Demonstrated a diuretic effect comparable to Hydrochlorothiazide and Quinethazone, though it was less potent than Furosemide at 50 mg/kg.
Excreted sodium in a dose-dependent manner, while potassium excretion did not increase proportionally with the dose.
Did not increase urinary calcium excretion, and there was no change in phosphorus excretion.
Did not rely on adrenal hormones.
Peso molecular

337.78

Fòrmula

C14H12ClN3O3S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

O=S(C1=CC2=C(NC(C3=CC=CC=C3)NC2=O)C=C1Cl)(N)=O
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvente y solubilidad
In Vitro: 

DMSO : 100 mg/mL (296.05 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9605 mL 14.8025 mL 29.6051 mL
5 mM 0.5921 mL 2.9605 mL 5.9210 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Calculadora de molaridad

  • Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (7.40 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureza y Documentación
Referencias

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.9605 mL 14.8025 mL 29.6051 mL 74.0127 mL
5 mM 0.5921 mL 2.9605 mL 5.9210 mL 14.8025 mL
10 mM 0.2961 mL 1.4803 mL 2.9605 mL 7.4013 mL
15 mM 0.1974 mL 0.9868 mL 1.9737 mL 4.9342 mL
20 mM 0.1480 mL 0.7401 mL 1.4803 mL 3.7006 mL
25 mM 0.1184 mL 0.5921 mL 1.1842 mL 2.9605 mL
30 mM 0.0987 mL 0.4934 mL 0.9868 mL 2.4671 mL
40 mM 0.0740 mL 0.3701 mL 0.7401 mL 1.8503 mL
50 mM 0.0592 mL 0.2961 mL 0.5921 mL 1.4803 mL
60 mM 0.0493 mL 0.2467 mL 0.4934 mL 1.2335 mL
80 mM 0.0370 mL 0.1850 mL 0.3701 mL 0.9252 mL
100 mM 0.0296 mL 0.1480 mL 0.2961 mL 0.7401 mL
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Fenquizone20287-37-0MG-13054MG13054MG 13054Potassium ChannelKcsAthiazide-like diureticchronic antihypertensive effectoedemahypertensionInhibitorinhibitorinhibit

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