2. Quinethazone

Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research.

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Quinethazone Chemical Structure

Quinethazone Chemical Structure

CAS No. : 73-49-4

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Quinethazone Related Antibodies

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Description

Quinethazone is an orally active diuretic agent and is also a weak inhibitor of carbonic anhydrase. Quinethazone can be used for hypertension research[1][2].

In Vivo

Quinethazone (50 mg/kg; p.o.; daily for 2 weeks) lowers blood pressure of renal hypertensive rats in association with a decrease in potassium but no change in water or sodium contents of aorta wall[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Five- to 6-week-old Long Evans male rats, hypertension model[1]
Dosage: 50 mg/kg
Administration: Oral, daily for 2 weeks
Result: Had no significant effect on sodium or water distribution in arterial tissue of hypertensive rats, but decreased approximate 20% intra-cellular content of potassium
Molecular Weight

289.74

Formula

C10H12ClN3O3S
CAS No.
SMILES

O=S(C1=CC2=C(NC(CC)NC2=O)C=C1Cl)(N)=O
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Keywords:

Quinethazone73-49-4Inhibitorinhibitorinhibit

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